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Ras and Rab interactor

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Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Below are the list of possible Ras and Rab interactor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ras and Rab interactor 1

 Ras and Rab interactor 1 ELISA Kit
 Ras and Rab interactor 1 Recombinant
 Ras and Rab interactor 1 Antibody
Also known as Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1).
Rin1: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which
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regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351. Expressed in all tissues examined with high levels in brain, placenta and pancreas. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding
 RIN1 ELISA Kit
 RIN1 Recombinant
 RIN1 Antibody
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Ras and Rab interactor 2

 Ras and Rab interactor 2 ELISA Kit
 Ras and Rab interactor 2 Recombinant
 Ras and Rab interactor 2 Antibody
Also known as Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2).
RIN2: Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for fre
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e GTP. Defects in RIN2 are the cause of MACS syndrome (MACS); also called macrocephaly alopecia cutis laxa and scoliosis syndrome. MACS is an autosomal-recessive inherited complex disorder of elastic tissue, characterized by sagging skin and occasionally by life-threatening visceral complications. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20p11.22

Disease: Macs Syndrome
 RIN2 ELISA Kit
 RIN2 Recombinant
 RIN2 Antibody
 RASSF4 ELISA Kit
 RASSF4 Recombinant
 RASSF4 Antibody
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Ras and Rab interactor 3

 Ras and Rab interactor 3 ELISA Kit
 Ras and Rab interactor 3 Recombinant
 Ras and Rab interactor 3 Antibody
Also known as Ras and Rab interactor 3 (Ras interaction/interference protein 3).
RIN3: Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.12
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Cellular Component: cytoplasmic vesicle; early endosome

Molecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity
 RIN3 ELISA Kit
 RIN3 Recombinant
 RIN3 Antibody
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