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Ras association domain-containing protein

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Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Below are the list of possible Ras association domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ras association domain-containing protein 1

 Ras association domain-containing protein 1 ELISA Kit
 Ras association domain-containing protein 1 Recombinant
 Ras association domain-containing protein 1 Antibody
RASSF1: Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of
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the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS1 via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53. Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. 8 isoforms of the human protein are produced by alternative promoter.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm; microtubule cytoskeleton; nucleus; plasma membrane

Molecular Function: protein binding; zinc ion binding

Biological Process: cell cycle arrest; Ras protein signal transduction

Disease: Lung Cancer
 RASSF1 ELISA Kit
 RASSF1 Recombinant
 RASSF1 Antibody
 RDA32 ELISA Kit
 RDA32 Recombinant
 RDA32 Antibody
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Ras association domain-containing protein 10

 Ras association domain-containing protein 10 ELISA Kit
 Ras association domain-containing protein 10 Recombinant
 Ras association domain-containing protein 10 Antibody
RASSF10:

Chromosomal Location of Human Ortholog: 11p15.2
 RASSF10 ELISA Kit
 RASSF10 Recombinant
 RASSF10 Antibody
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Ras association domain-containing protein 2

 Ras association domain-containing protein 2 ELISA Kit
 Ras association domain-containing protein 2 Recombinant
 Ras association domain-containing protein 2 Antibody
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation ().
 Rassf2 ELISA Kit
 Rassf2 Recombinant
 Rassf2 Antibody
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Ras association domain-containing protein 3

 Ras association domain-containing protein 3 ELISA Kit
 Ras association domain-containing protein 3 Recombinant
 Ras association domain-containing protein 3 Antibody
RASSF3: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q14.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: identical protein binding; protein binding
 RASSF3 ELISA Kit
 RASSF3 Recombinant
 RASSF3 Antibody
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Ras association domain-containing protein 4

 Ras association domain-containing protein 4 ELISA Kit
 Ras association domain-containing protein 4 Recombinant
 Ras association domain-containing protein 4 Antibody
RASSF4: Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 10q11.21

Molecular Function: protein binding
 RASSF4 ELISA Kit
 RASSF4 Recombinant
 RASSF4 Antibody
 AD037 ELISA Kit
 AD037 Recombinant
 AD037 Antibody
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Ras association domain-containing protein 5

 Ras association domain-containing protein 5 ELISA Kit
 Ras association domain-containing protein 5 Recombinant
 Ras association domain-containing protein 5 Antibody
Also known as Ras association domain-containing protein 5 (Maxp1) (New ras effector 1).
RASSF5: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to I
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CAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor

Cellular Component: nucleus

Biological Process: negative regulation of cell proliferation; positive regulation of protein ubiquitination
 Rassf5 ELISA Kit
 Rassf5 Recombinant
 Rassf5 Antibody
 Nore1 ELISA Kit
 Nore1 Recombinant
 Nore1 Antibody
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Ras association domain-containing protein 6

 Ras association domain-containing protein 6 ELISA Kit
 Ras association domain-containing protein 6 Recombinant
 Ras association domain-containing protein 6 Antibody
Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.
 Rassf6 ELISA Kit
 Rassf6 Recombinant
 Rassf6 Antibody
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Ras association domain-containing protein 7

 Ras association domain-containing protein 7 ELISA Kit
 Ras association domain-containing protein 7 Recombinant
 Ras association domain-containing protein 7 Antibody
HRC1: 2 isoforms of the human protein are produced by alternative splicing.
 Rassf7 ELISA Kit
 Rassf7 Recombinant
 Rassf7 Antibody
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Ras association domain-containing protein 8

 Ras association domain-containing protein 8 ELISA Kit
 Ras association domain-containing protein 8 Recombinant
 Ras association domain-containing protein 8 Antibody
Also known as Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).
RASSF8: A chromosomal aberration involving RASSF8 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with C12orf2. 2 isoforms of the human protein are produ
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ced by alternative splicing.
 Rassf8 ELISA Kit
 Rassf8 Recombinant
 Rassf8 Antibody
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Ras association domain-containing protein 9

 Ras association domain-containing protein 9 ELISA Kit
 Ras association domain-containing protein 9 Recombinant
 Ras association domain-containing protein 9 Antibody
Also known as Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor).
RASSF9: May play a role in regulating vesicuar trafficking in cells.

Chromosomal Location of Human Ortholog: 12q21.31

Cellular Component: cytosol; endosome; trans-Golgi network transport vesicle membrane

Molecular Function: protein binding
 RASSF9 ELISA Kit
 RASSF9 Recombinant
 RASSF9 Antibody
 PAMCI ELISA Kit
 PAMCI Recombinant
 PAMCI Antibody
 PCIP1 ELISA Kit
 PCIP1 Recombinant
 PCIP1 Antibody
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