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Ras GTPase-activating protein-binding protein

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May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.

Below are the list of possible Ras GTPase-activating protein-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ras GTPase-activating protein-binding protein 1

 Ras GTPase-activating protein-binding protein 1 ELISA Kit
 Ras GTPase-activating protein-binding protein 1 Recombinant
 Ras GTPase-activating protein-binding protein 1 Antibody
Also known as Ras GTPase-activating protein-binding protein 1 (G3BP-1) (ATP-dependent DNA helicase VIII) (GAP SH3 domain-binding protein 1) (HDH-VIII).
G3BP-1: an hnRNA-binding protein and endoribonuclease that participates in the Ras signal transduction pathway. A regulated effector of stress granule (SG) assembly. SGs are involved in mRNA sorting in the storing of untranslated mRNAs. Cleaves
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exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Binds to the SH3 domain of Ras GTPase-activating protein (RasGAP) in proliferating cells but not in quiescent cells. Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells. Cytosolic and partially nuclear in resting cells. Recruited to SGs upon either arsenite or high temperature treatment. RasGAP-dependent phosphorylation of S149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. S149 phosphorylation induces partial nuclear localization. A component of a TAU mRNP complex, Interacts with USP10, and may regulate it.

Protein type: Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding

Cellular Component: cytoplasm; cytosol; focal adhesion; stress granule

Molecular Function: mRNA binding; protein binding
 G3bp1 ELISA Kit
 G3bp1 Recombinant
 G3bp1 Antibody
 G3bp ELISA Kit
 G3bp Recombinant
 G3bp Antibody
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Ras GTPase-activating protein-binding protein 2

 Ras GTPase-activating protein-binding protein 2 ELISA Kit
 Ras GTPase-activating protein-binding protein 2 Recombinant
 Ras GTPase-activating protein-binding protein 2 Antibody
Also known as Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2).
G3BP-2: an hnRNA-binding protein and an element of the Ras signal transduction pathway. A DNA-unwinding enzyme which can unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. Binds specifically to the Ras-GTPase-activating protein (GAP120) by associating with its SH3 do
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main. Interacts with USP10, and may regulate it. Several alternatively spliced transcript variants have been described.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: cytoplasm; cytosol; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding
 G3BP2 ELISA Kit
 G3BP2 Recombinant
 G3BP2 Antibody
 KIAA0660 ELISA Kit
 KIAA0660 Recombinant
 KIAA0660 Antibody
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