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Ras/Rap GTPase-activating protein

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).

Below are the list of possible Ras/Rap GTPase-activating protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Ras/Rap GTPase-activating protein SynGAP

 Ras/Rap GTPase-activating protein SynGAP ELISA Kit
 Ras/Rap GTPase-activating protein SynGAP Recombinant
 Ras/Rap GTPase-activating protein SynGAP Antibody
Also known as Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1).
SynGAP: an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knoc
kout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described.

Protein type: GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; cytosol

Molecular Function: GTPase activator activity

Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; regulation of synaptic plasticity

Disease: Mental Retardation, Autosomal Dominant 5
 SYNGAP1 Recombinant
 SYNGAP1 Antibody
 KIAA1938 Recombinant
 KIAA1938 Antibody
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