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RB1-inducible coiled-coil protein

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Involved in autophagy .

Below are the list of possible RB1-inducible coiled-coil protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

RB1-inducible coiled-coil protein 1

 RB1-inducible coiled-coil protein 1 ELISA Kit
 RB1-inducible coiled-coil protein 1 Recombinant
 RB1-inducible coiled-coil protein 1 Antibody
Also known as RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180).
RB1CC1: a putative transcription factor that functions as a key regulator of Rb expression. Required for autophagosome formation. Contains a nuclear localization signal, a leucine zipper motif and a coiled-coil structure. Thought to play a biological role in controlling cell growth and progression of various cancers. Probably involved in the tumorigenesis of breast cancer. It is frequently mutated in breast cancer and shows characteristics
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of a classical tumor suppressor gene. Plays a crucial role in muscular differentiation and required for myogenic differentiation. Part of a complex consisting of ATG13, ULK1 and RB1CC1. This complex associates with ATG101. Under starvation conditions, is localized to phagophores. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells in embryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletal muscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminal differentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation of macroscopic colonies in a cell growth assay.

Protein type: Autophagy; DNA-binding; Transcription factor; Tumor suppressor

Cellular Component: cytoplasm; nuclear membrane; nucleus; pre-autophagosomal structure membrane

Molecular Function: protein binding; protein complex scaffold; protein kinase binding

Biological Process: autophagic vacuole formation; autophagy; cellular response to nitrogen starvation; heart development; liver development; mitochondrion degradation; negative regulation of apoptosis; peroxisome degradation; positive regulation of cell size; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation
 Rb1cc1 ELISA Kit
 Rb1cc1 Recombinant
 Rb1cc1 Antibody
 Cc1 ELISA Kit
 Cc1 Recombinant
 Cc1 Antibody
 Kiaa0203 ELISA Kit
 Kiaa0203 Recombinant
 Kiaa0203 Antibody
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