Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Receptor-interacting serine/threonine-protein kinase  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • VHL (Ab-68) Antibody
 • EFNB1 (Ab-317) Antibody
 • Cortisone ELISA Kit
 • Apelin 13 (APELIN -13) ELISA Kit
 • Integrin beta4 (ITGbeta4) ELISA Kit
 • Colicin ELISA Kit
 • Glia Maturation Factor Beta (GMFB) ELISA Kit
 • Mutated Citrullinated VImentin Antibody (MCV) ELISA Kit
 • Immunoglobulin G4 (IgG4) ELISA Kit
 • Kruppel Like Factor 15 (KLF15) ELISA Kit
 • Vascular Endothelial Cell Growth Factor (VEGF165) ELISA Kit
 • Galectin 3 (GAL3) ELISA Kit
 • Fibrillin 1 (FBN1) ELISA Kit
 • Trypsin Antibody ELISA Kit
 downarrow more ...
separator

Receptor-interacting serine/threonine-protein kinase

separator
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).

Below are the list of possible Receptor-interacting serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Receptor-interacting serine/threonine-protein kinase 1

 Receptor-interacting serine/threonine-protein kinase 1 ELISA Kit
 Receptor-interacting serine/threonine-protein kinase 1 Recombinant
 Receptor-interacting serine/threonine-protein kinase 1 Antibody
Also known as Receptor-interacting serine/threonine-protein kinase 1 (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP).
RIPK1: Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream sig
>>>
nal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex. Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif); this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Inhibited by necrostatin-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group

Cellular Component: cytoplasm; lipid raft; mitochondrion; protein complex; receptor complex

Molecular Function: death receptor binding; identical protein binding; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; cellular protein catabolic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of macrophage differentiation; positive regulation of MAPKKK cascade; positive regulation of phosphorylation; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transferase activity; positive regulation of tumor necrosis factor production; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization
 Ripk1 ELISA Kit
 Ripk1 Recombinant
 Ripk1 Antibody
 Rinp ELISA Kit
 Rinp Recombinant
 Rinp Antibody
 Rip ELISA Kit
 Rip Recombinant
 Rip Antibody
Table BarTOPTable Bar
 

Receptor-interacting serine/threonine-protein kinase 2

 Receptor-interacting serine/threonine-protein kinase 2 ELISA Kit
 Receptor-interacting serine/threonine-protein kinase 2 Recombinant
 Receptor-interacting serine/threonine-protein kinase 2 Antibody
Also known as Receptor-interacting serine/threonine-protein kinase 2 (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-.
RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.

Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group

Chromosomal Location o
>>>
f Human Ortholog: 8q21

Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle

Molecular Function: CARD domain binding; identical protein binding; LIM domain binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; adaptive immune response; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; JNK cascade; MAPKKK cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; signal transduction; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway
 RIPK2 ELISA Kit
 RIPK2 Recombinant
 RIPK2 Antibody
 CARDIAK ELISA Kit
 CARDIAK Recombinant
 CARDIAK Antibody
 RICK ELISA Kit
 RICK Recombinant
 RICK Antibody
 RIP2 ELISA Kit
 RIP2 Recombinant
 RIP2 Antibody
Table BarTOPTable Bar
 

Receptor-interacting serine/threonine-protein kinase 3

 Receptor-interacting serine/threonine-protein kinase 3 ELISA Kit
 Receptor-interacting serine/threonine-protein kinase 3 Recombinant
 Receptor-interacting serine/threonine-protein kinase 3 Antibody
Also known as Receptor-interacting serine/threonine-protein kinase 3 (Homocysteine respondent protein HCYP2) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).
RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produ
>>>
ced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group

Cellular Component: cytosol; intracellular

Molecular Function: identical protein binding; NF-kappaB-inducing kinase activity; protein complex binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of NF-kappaB transcription factor; activation of protein kinase activity; I-kappaB kinase/NF-kappaB cascade; lymph node development; positive regulation of ligase activity; positive regulation of oxidoreductase activity; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization; regulation of activated T cell proliferation; regulation of adaptive immune response; regulation of interferon-gamma production; regulation of T cell mediated cytotoxicity; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development
 Ripk3 ELISA Kit
 Ripk3 Recombinant
 Ripk3 Antibody
 Rip3 ELISA Kit
 Rip3 Recombinant
 Rip3 Antibody
Table BarTOPTable Bar
 

Receptor-interacting serine/threonine-protein kinase 4

 Receptor-interacting serine/threonine-protein kinase 4 ELISA Kit
 Receptor-interacting serine/threonine-protein kinase 4 Recombinant
 Receptor-interacting serine/threonine-protein kinase 4 Antibody
Also known as Receptor-interacting serine/threonine-protein kinase 4 (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase).
ANKRD3: a TKL protein kinase of the RIPK family. Activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. Appears to activate NFkappaB in both a kinase-dependent as well as a kinase-independent manner. Contains 10 ANK repeats. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-
>>>
receptor); Protein kinase, TKL; RIPK family; TKL group

Cellular Component: cytoplasm

Biological Process: activation of NF-kappaB transcription factor; morphogenesis of an epithelium
 Ripk4 ELISA Kit
 Ripk4 Recombinant
 Ripk4 Antibody
 Ankrd3 ELISA Kit
 Ankrd3 Recombinant
 Ankrd3 Antibody
 Pkk ELISA Kit
 Pkk Recombinant
 Pkk Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions