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Receptor of activated protein C kinase

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Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).

Below are the list of possible Receptor of activated protein C kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Receptor of activated protein C kinase 1

 Receptor of activated protein C kinase 1 ELISA Kit
 Receptor of activated protein C kinase 1 Recombinant
 Receptor of activated protein C kinase 1 Antibody
Also known as Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205).
RACK1: a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-me
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diated Akt activation and protection from cell death.

Protein type: Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Cellular Component: cell soma; cell-cell adherens junction; cytoplasm; cytosol; dendrite; membrane; midbody; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; phagocytic cup; small ribosomal subunit

Molecular Function: caspase activator activity; enzyme binding; ion channel inhibitor activity; protein binding; protein homodimerization activity; protein kinase C binding; protein phosphatase binding; protein tyrosine kinase inhibitor activity; receptor activity; receptor tyrosine kinase binding; SH2 domain binding

Biological Process: caspase activation; negative regulation of cell growth; negative regulation of peptidyl-serine phosphorylation; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of translation; osteoblast differentiation; pigmentation; positive regulation of apoptosis; positive regulation of cAMP catabolic process; positive regulation of cell migration; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of Golgi to plasma membrane protein transport; positive regulation of GTPase activity; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of protein homooligomerization; protein localization; regulation of cell cycle; translation
 Rack1 ELISA Kit
 Rack1 Recombinant
 Rack1 Antibody
 Gnb2-rs1 ELISA Kit
 Gnb2-rs1 Recombinant
 Gnb2-rs1 Antibody
 Gnb2l1 ELISA Kit
 Gnb2l1 Recombinant
 Gnb2l1 Antibody
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