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Receptor-type tyrosine-protein kinase

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Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Below are the list of possible Receptor-type tyrosine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Receptor-type tyrosine-protein kinase FLT3

 Receptor-type tyrosine-protein kinase FLT3 ELISA Kit
 Receptor-type tyrosine-protein kinase FLT3 Recombinant
 Receptor-type tyrosine-protein kinase FLT3 Antibody
Also known as Receptor-type tyrosine-protein kinase FLT3 (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135).
FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promye
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locytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: cell surface; cytoplasm; cytosol; external side of plasma membrane; nucleus; plasma membrane; protein complex

Molecular Function: glucocorticoid receptor binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: antigen processing and presentation; B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; homeostasis of number of cells within a tissue; leukocyte homeostasis; lymph node development; lymphocyte differentiation; lymphocyte proliferation; lymphoid progenitor cell differentiation; myeloid progenitor cell differentiation; negative regulation of B cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; positive regulation of interferon-alpha production; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of multicellular organism growth; positive regulation of protein amino acid phosphorylation; post-embryonic development; pro-B cell differentiation; pro-T cell differentiation; protein amino acid autophosphorylation; spleen development
 Flt3 ELISA Kit
 Flt3 Recombinant
 Flt3 Antibody
 Flk-2 ELISA Kit
 Flk-2 Recombinant
 Flk-2 Antibody
 Flt-3 ELISA Kit
 Flt-3 Recombinant
 Flt-3 Antibody
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