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Receptor tyrosine-protein kinase

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Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (By similarity).

Below are the list of possible Receptor tyrosine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Receptor tyrosine-protein kinase erbB-2

 Receptor tyrosine-protein kinase erbB-2 ELISA Kit
 Receptor tyrosine-protein kinase erbB-2 Recombinant
 Receptor tyrosine-protein kinase erbB-2 Antibody
Also known as Receptor tyrosine-protein kinase erbB-2 (Epidermal growth factor receptor-related protein) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (p185erbB2) (p185neu) (CD antigen CD340).
HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- a
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lpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; endosome membrane; lateral loop; lipid raft; microvillus; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; receptor complex

Molecular Function: glycoprotein binding; growth factor binding; Hsp90 protein binding; identical protein binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; protein-tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: cell surface receptor linked signal transduction; central nervous system development; glial cell differentiation; heart development; liver development; mammary gland involution; motor axon guidance; myelination; negative regulation of apoptosis; negative regulation of immature T cell proliferation in the thymus; nervous system development; neuromuscular junction development; oligodendrocyte differentiation; peripheral nervous system development; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; regulation of cell differentiation; regulation of cell proliferation; regulation of microtubule-based process; response to axon injury; response to drug; response to progesterone stimulus; signal transduction; skeletal muscle development; sympathetic nervous system development; tongue development; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
 Erbb2 ELISA Kit
 Erbb2 Recombinant
 Erbb2 Antibody
 Neu ELISA Kit
 Neu Recombinant
 Neu Antibody
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Receptor tyrosine-protein kinase erbB-3

 Receptor tyrosine-protein kinase erbB-3 ELISA Kit
 Receptor tyrosine-protein kinase erbB-3 Recombinant
 Receptor tyrosine-protein kinase erbB-3 Antibody
Also known as Receptor tyrosine-protein kinase erbB-3 (Glial growth factor receptor) (Proto-oncogene-like protein c-ErbB-3).
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2
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activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; lateral plasma membrane; nucleus; postsynaptic membrane; receptor complex

Molecular Function: growth factor binding; protein binding; protein heterodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity

Biological Process: cranial nerve development; epidermal growth factor receptor signaling pathway; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; positive regulation of cardiac muscle development; positive regulation of glucose import; regulation of cell proliferation; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
 Erbb3 ELISA Kit
 Erbb3 Recombinant
 Erbb3 Antibody
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Receptor tyrosine-protein kinase erbB-4

 Receptor tyrosine-protein kinase erbB-4 ELISA Kit
 Receptor tyrosine-protein kinase erbB-4 Recombinant
 Receptor tyrosine-protein kinase erbB-4 Antibody
Also known as Receptor tyrosine-protein kinase erbB-4 (Proto-oncogene-like protein c-ErbB-4).
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not a
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ctivated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: basolateral plasma membrane; caveola; cytoplasm; lipid raft; mitochondrion; nucleus; plasma membrane; postsynaptic density; receptor complex

Molecular Function: epidermal growth factor receptor binding; protein homodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: cell fate commitment; cell migration; central nervous system morphogenesis; embryonic pattern specification; heart development; lactation; mitochondrial fragmentation during apoptosis; negative regulation of apoptosis; negative regulation of cell proliferation; nervous system development; neural crest cell migration; olfactory bulb interneuron differentiation; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of glucose import; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of synaptic transmission, GABAergic; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid autophosphorylation; regulation of cell migration; signal transduction; surfactant homeostasis; synapse maturation; transmembrane receptor protein tyrosine kinase signaling pathway
 Erbb4 ELISA Kit
 Erbb4 Recombinant
 Erbb4 Antibody
 Mer4 ELISA Kit
 Mer4 Recombinant
 Mer4 Antibody
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Receptor tyrosine-protein kinase let-23

 Receptor tyrosine-protein kinase let-23 ELISA Kit
 Receptor tyrosine-protein kinase let-23 Recombinant
 Receptor tyrosine-protein kinase let-23 Antibody
Also known as Receptor tyrosine-protein kinase let-23 (Lethal protein 23).
Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca2+ signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis (PubMed:2071015, PubMed:8313880, PubMed:9491893). Probably by activating
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phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions (PubMed:9491893, PubMed:15194811). Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3 (PubMed:17891142).
 let-23 ELISA Kit
 let-23 Recombinant
 let-23 Antibody
 kin-7 ELISA Kit
 kin-7 Recombinant
 kin-7 Antibody
 ZK1067.1 ELISA Kit
 ZK1067.1 Recombinant
 ZK1067.1 Antibody
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