A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. Senses changes in the intracellular redox state and helps mediate a metabolic switchover to preferred in vivo carbon sources (fatty acids). The apo- but not holo-form probably binds DNA (By similarity). Plays a role in virulence .
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