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Reducing polyketide synthase

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Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties .

Below are the list of possible Reducing polyketide synthase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Reducing polyketide synthase FUB1

 Reducing polyketide synthase FUB1 ELISA Kit
 Reducing polyketide synthase FUB1 Recombinant
 Reducing polyketide synthase FUB1 Antibody
Also known as Reducing polyketide synthase FUB1 (Fusaric acid biosynthesis protein 1).
Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:24389666, PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is
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activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).
 FUB1 ELISA Kit
 FUB1 Recombinant
 FUB1 Antibody
 FFUJ_02105 ELISA Kit
 FFUJ_02105 Recombinant
 FFUJ_02105 Antibody
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Reducing polyketide synthase hmp8

 Reducing polyketide synthase hmp8 ELISA Kit
 Reducing polyketide synthase hmp8 Recombinant
 Reducing polyketide synthase hmp8 Antibody
Also known as Reducing polyketide synthase hmp8 (R-PKS hmp8) (Hypothemycin biosynthesis cluster protein hpm8).
Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of hypothemycin, a resorcylic acid lactone (RAL) that irreversibly inhibits a subset of protein kinases with a conserved cysteine in the ATP binding site such as human ERK2 (PubMed:18567690, PubMed:20
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222707, PubMed:22406519, PubMed:23356934). The first step is performed by both PKSs hmp3 and hmp8 and leads to the production of 7',8'-dehydrozearalenol (DHZ) (PubMed:18567690, PubMed:20222707). The highly reducing PKS hpm8 synthesizes the reduced hexaketide (7S,11S,2E,8E)-7,11-dihydroxy-dodeca-2,8-dienoate, which is transferred downstream to the non-reducing PKS hpm3 (PubMed:20222707, PubMed:22406519, PubMed:23356934). Hpm3 then extends the reduced hexaketide to a nonaketide, after which regioselective cyclization and macrolactonization affords DHZ (PubMed:20222707, PubMed:22406519, PubMed:23356934). The next step is the conversion of DHZ into aigialomycin C and is performed by the O-methyltransferase hmp5, the FAD-binding monooxygenase hmp7, and the cytochrome P450 monooxygenase hmp1 (PubMed:18567690). The wide substrate tolerance of the hmp5 and hmp7 implies that the reactions from DHZ to aigialomycin C can occur in any order (PubMed:18567690). The steps from aigialomycin C to hypothemycin are less well established (PubMed:18567690). The FAD-linked oxidoreductase hmp9 presumably catalyzes oxidation of the C-6' hydroxyl to a ketone (PubMed:18567690). The timing of this oxidation is important, since the resulting enone functional group is a Michael acceptor that can react spontaneously with glutathione, an abundant metabolite in fungal cells (PubMed:18567690). The glutathione S-transferase hmp2 catalyzes cis-trans isomerization of the 7',8' double bond with equilibrium favoring the trans isomer (PubMed:18567690). The hpm6-encoded transporter might preferentially pump hypothemycin out of the cell relative to the trans isomer aigialomycin A. The cis-to-trans isomerization may be coupled with C-4' hydroxylation, since all known hypothemycin analogs containing the enone functional group also have hydroxyl groups at both C-4' and C-5' (PubMed:18567690).
 hpm8 ELISA Kit
 hpm8 Recombinant
 hpm8 Antibody
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Reducing polyketide synthase PKS1

 Reducing polyketide synthase PKS1 ELISA Kit
 Reducing polyketide synthase PKS1 Recombinant
 Reducing polyketide synthase PKS1 Antibody
Also known as Reducing polyketide synthase PKS1 (T-toxin biosynthesis protein PKS1).
Reducing polyketide synthase (PKS); part of the Tox1A locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize (PubMed:8953776, PubMed:20192833). One of the
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PKSs (PKS1 or PKS2) could synthesize a precursor, used subsequently by the other PKS as starter unit, to add additional carbons (PubMed:16529376). Variability in the length of the final carbon backbone C35-47 could be achieved by varying the number of condensation cycles, or use of different starter or extender units or might be due to decarboxylation of the penultimate product, catalyzed by DEC1 (PubMed:12236595). Additional proteins are required for the biosynthesis of T-toxin, including oxidoreductases RED1, RED2, RED3, LAM1 and OXI1, as well as esterase TOX9 (PubMed:20192833).
 PKS1 ELISA Kit
 PKS1 Recombinant
 PKS1 Antibody
 COCC4DRAFT_45906 ELISA Kit
 COCC4DRAFT_45906 Recombinant
 COCC4DRAFT_45906 Antibody
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Reducing polyketide synthase PKS2

 Reducing polyketide synthase PKS2 ELISA Kit
 Reducing polyketide synthase PKS2 Recombinant
 Reducing polyketide synthase PKS2 Antibody
Also known as Reducing polyketide synthase PKS2 (T-toxin biosynthesis protein PKS2).
Reducing polyketide synthase (PKS); part of the Tox1A locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize (PubMed:8953776, PubMed:20192833). One of the
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PKSs (PKS1 or PKS2) could synthesize a precursor, used subsequently by the other PKS as starter unit, to add additional carbons (PubMed:16529376). Variability in the length of the final carbon backbone C35-47 could be achieved by varying the number of condensation cycles, or use of different starter or extender units or might be due to decarboxylation of the penultimate product, catalyzed by DEC1 (PubMed:12236595). Additional proteins are required for the biosynthesis of T-toxin, including oxidoreductases RED1, RED2, RED3, LAM1 and OXI1, as well as esterase TOX9 (PubMed:20192833).
 PKS2 ELISA Kit
 PKS2 Recombinant
 PKS2 Antibody
 COCC4DRAFT_45941 ELISA Kit
 COCC4DRAFT_45941 Recombinant
 COCC4DRAFT_45941 Antibody
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Reducing polyketide synthase rdc5

 Reducing polyketide synthase rdc5 ELISA Kit
 Reducing polyketide synthase rdc5 Recombinant
 Reducing polyketide synthase rdc5 Antibody
Also known as Reducing polyketide synthase rdc5 (R-PKS rdc5) (Hypothemycin biosynthesis cluster protein rdc5).
Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy (PubMed:18567690). The cluster encodes only two appa
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rent post-PKS enzymes, a cytochrome P450 monooxygenase (rdc4) and a non-heme halogenase (rdc2) that could introduce the epoxide and the chlorine, respectively (PubMed:18567690). If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rdc1 and rdc5 (PubMed:18567690). The C-2' ketone could arise if the R-PKS rdc5 and NR-PKS rdc1 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs (PubMed:18567690). The origin of the cis 5',6' double bond is not known (PubMed:18567690). The radicicol R-PKS rdc5 ER domain may catalyze either double bond isomerization or reduction in the third iteration (PubMed:18567690).
 rdc5 ELISA Kit
 rdc5 Recombinant
 rdc5 Antibody
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