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Regulator of cell cycle

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Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Below are the list of possible Regulator of cell cycle products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Regulator of cell cycle RGCC

 Regulator of cell cycle RGCC ELISA Kit
 Regulator of cell cycle RGCC Recombinant
 Regulator of cell cycle RGCC Antibody
Also known as Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32).
RGC32: modulates the activity of cell cycle-specific kinases. Interacts with CDK1 and PLK1. Enhances CDK1 activity and contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to
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the pathogenesis of renal fibrosis through fibroblast activation. Interacts with SMAD3. Cytoplasmic in unstimulated cells; translocates to the nucleus following activation by complement. Associated with the centrosome during prometaphase and metaphase. Induced by Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation. Important in vascular smooth muscle cell (VSMC) differentiation following transforming growth factor-beta (TGF-beta) induction. Its expression is greatly induced by TGF-beta in neural crest cells, leading to the induction of VSMC gene promoters. Smad and RhoA signaling are important for RGC-32 activation in neural crest cells. Forms a complex with hnRNP A/B that regulates the transcription of VSMC differentiation genes. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Protein kinase, regulatory subunit

Cellular Component: centrosome; cytoplasm; nucleus

Molecular Function: protein binding; protein kinase activator activity; protein kinase binding

Biological Process: complement activation; G1/S transition of mitotic cell cycle; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; negative regulation of cytokine secretion; negative regulation of endothelial cell proliferation; negative regulation of exit from mitosis; positive regulation of collagen biosynthetic process; positive regulation of cytokine secretion; positive regulation of mitosis; positive regulation of stress fiber formation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter
 Rgcc ELISA Kit
 Rgcc Recombinant
 Rgcc Antibody
 Rgc32 ELISA Kit
 Rgc32 Recombinant
 Rgc32 Antibody
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