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Regulator of nonsense transcripts

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RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability.

Below are the list of possible Regulator of nonsense transcripts products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Regulator of nonsense transcripts 1

 Regulator of nonsense transcripts 1 ELISA Kit
 Regulator of nonsense transcripts 1 Recombinant
 Regulator of nonsense transcripts 1 Antibody
Also known as Regulator of nonsense transcripts 1 (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1).
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located onl
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y in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
 UPF1 ELISA Kit
 UPF1 Recombinant
 UPF1 Antibody
 KIAA0221 ELISA Kit
 KIAA0221 Recombinant
 KIAA0221 Antibody
 RENT1 ELISA Kit
 RENT1 Recombinant
 RENT1 Antibody
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Regulator of nonsense transcripts 1 homolog

 Regulator of nonsense transcripts 1 homolog ELISA Kit
 Regulator of nonsense transcripts 1 homolog Recombinant
 Regulator of nonsense transcripts 1 homolog Antibody
RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD ().
 Upf1 ELISA Kit
 Upf1 Recombinant
 Upf1 Antibody
 CG1559 ELISA Kit
 CG1559 Recombinant
 CG1559 Antibody
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Regulator of nonsense transcripts 2

 Regulator of nonsense transcripts 2 ELISA Kit
 Regulator of nonsense transcripts 2 Recombinant
 Regulator of nonsense transcripts 2 Antibody
Also known as Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).
UPF2: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and R
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NA helicase activities of UPF1. Binds spliced mRNA. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 10p14-p13

Cellular Component: cytoplasm; cytosol; nucleus; polysome

Molecular Function: protein binding; telomeric DNA binding

Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus
 UPF2 ELISA Kit
 UPF2 Recombinant
 UPF2 Antibody
 KIAA1408 ELISA Kit
 KIAA1408 Recombinant
 KIAA1408 Antibody
 RENT2 ELISA Kit
 RENT2 Recombinant
 RENT2 Antibody
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Regulator of nonsense transcripts 3A

 Regulator of nonsense transcripts 3A ELISA Kit
 Regulator of nonsense transcripts 3A Recombinant
 Regulator of nonsense transcripts 3A Antibody
Also known as Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).
UPF3A: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown
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to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. Belongs to the RENT3 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus; plasma membrane

Molecular Function: protein binding; telomeric DNA binding

Biological Process: mRNA catabolic process, nonsense-mediated decay; positive regulation of translation
 UPF3A ELISA Kit
 UPF3A Recombinant
 UPF3A Antibody
 RENT3A ELISA Kit
 RENT3A Recombinant
 RENT3A Antibody
 UPF3 ELISA Kit
 UPF3 Recombinant
 UPF3 Antibody
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Regulator of nonsense transcripts 3B

 Regulator of nonsense transcripts 3B ELISA Kit
 Regulator of nonsense transcripts 3B Recombinant
 Regulator of nonsense transcripts 3B Antibody
Also known as Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X).
UPF3B: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stall
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ed ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is indepenedent of association with UPF2 and components of the EJC core. Defects in UPF3B are the cause of mental retardation syndromic X-linked type 14 (MRXS14). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXS14 patients manifest mental retardation associated with other variable signs such as autistic features, slender build, poor musculature, long, thin face, high-arched palate, high nasal bridge, and pectus deformities. Belongs to the RENT3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleolus; nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding

Biological Process: mRNA 3'-end processing; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; positive regulation of translation; RNA export from nucleus; termination of RNA polymerase II transcription

Disease: Mental Retardation, X-linked, Syndromic 14
 UPF3B ELISA Kit
 UPF3B Recombinant
 UPF3B Antibody
 RENT3B ELISA Kit
 RENT3B Recombinant
 RENT3B Antibody
 UPF3X ELISA Kit
 UPF3X Recombinant
 UPF3X Antibody
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Regulator of nonsense transcripts UPF2

 Regulator of nonsense transcripts UPF2 ELISA Kit
 Regulator of nonsense transcripts UPF2 Recombinant
 Regulator of nonsense transcripts UPF2 Antibody
Also known as Regulator of nonsense transcripts UPF2 (Nonsense mRNA reducing factor UPF2) (Up-frameshift suppressor 2 homolog) (AtUpf2).
Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (). Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by asso
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ciating with the nuclear exon junction complex (EJC). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
 UPF2 ELISA Kit
 UPF2 Recombinant
 UPF2 Antibody
 At2g39260 ELISA Kit
 At2g39260 Recombinant
 At2g39260 Antibody
 T16B24.10 ELISA Kit
 T16B24.10 Recombinant
 T16B24.10 Antibody
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Regulator of nonsense transcripts UPF3

 Regulator of nonsense transcripts UPF3 ELISA Kit
 Regulator of nonsense transcripts UPF3 Recombinant
 Regulator of nonsense transcripts UPF3 Antibody
Also known as Regulator of nonsense transcripts UPF3 (Nonsense mRNA reducing factor UPF3) (Up-frameshift suppressor 3 homolog) (AtUpf3).
Involved in mRNA surveillance, detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD)
 UPF3 ELISA Kit
 UPF3 Recombinant
 UPF3 Antibody
 At1g33980 ELISA Kit
 At1g33980 Recombinant
 At1g33980 Antibody
 F12G12.20 ELISA Kit
 F12G12.20 Recombinant
 F12G12.20 Antibody
 T15K4.3 ELISA Kit
 T15K4.3 Recombinant
 T15K4.3 Antibody
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