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Regulatory-associated protein

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Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

Below are the list of possible Regulatory-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Regulatory-associated protein of mTOR

 Regulatory-associated protein of mTOR ELISA Kit
 Regulatory-associated protein of mTOR Recombinant
 Regulatory-associated protein of mTOR Antibody
Also known as Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein).
Raptor: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in respo
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nse to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Interacts with MTOR. Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Binds directly to 4EBP1 and RPS6KB1 independently of its association with MTOR. Binds preferentially to poorly or non-phosphorylated forms of EIF4EBP1, and this binding is critical to the ability of MTOR to catalyze phosphorylation. Forms a complex with MTOR under both leucine-rich and -poor conditions. Interacts with ULK1 in a nutrient-dependent manner; the interaction is reduced during starvation. Interacts (when phosphorylated by AMPK) with 14-3-3 protein, leading to inhibit its activity. Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Belongs to the WD repeat RAPTOR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cell soma; cytoplasm; dendrite; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleoplasm

Molecular Function: protein binding, bridging; protein complex binding; protein kinase activator activity; protein kinase binding

Biological Process: cell growth; cellular response to nutrient levels; negative regulation of insulin secretion; positive regulation of endothelial cell proliferation; positive regulation of TOR signaling pathway; positive regulation of transcription from RNA polymerase III promoter; regulation of cell size; regulation of phosphorylation; regulation of protein amino acid phosphorylation; TOR signaling pathway
 Rptor ELISA Kit
 Rptor Recombinant
 Rptor Antibody
 Raptor ELISA Kit
 Raptor Recombinant
 Raptor Antibody
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Regulatory-associated protein of TOR 1

 Regulatory-associated protein of TOR 1 ELISA Kit
 Regulatory-associated protein of TOR 1 Recombinant
 Regulatory-associated protein of TOR 1 Antibody
Also known as Regulatory-associated protein of TOR 1 (Protein RAPTOR 1) (OsRAPTOR1).
Probable component of the plant TOR kinase pathway.
 RAPTOR1 ELISA Kit
 RAPTOR1 Recombinant
 RAPTOR1 Antibody
 Os12g0110000 ELISA Kit
 Os12g0110000 Recombinant
 Os12g0110000 Antibody
 LOC_Os12g01922 ELISA Kit
 LOC_Os12g01922 Recombinant
 LOC_Os12g01922 Antibody
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Regulatory-associated protein of TOR 2

 Regulatory-associated protein of TOR 2 ELISA Kit
 Regulatory-associated protein of TOR 2 Recombinant
 Regulatory-associated protein of TOR 2 Antibody
Also known as Regulatory-associated protein of TOR 2 (Protein RAPTOR 1A) (AtRaptor1a) (Protein RAPTOR 2).
Encodes one of two Arabidopsis RAPTOR/KOG1 homologs. RAPTOR proteins are binding partners of the target of rapamycin kinase that is present in all eukaryotes and play a central role in the stimulation of cell growth and metabolism in response to nutrients. Mutations in this gene have no visible effects on embryo or plant development.
 RAPTOR2 ELISA Kit
 RAPTOR2 Recombinant
 RAPTOR2 Antibody
 RAPTOR1A ELISA Kit
 RAPTOR1A Recombinant
 RAPTOR1A Antibody
 At5g01770 ELISA Kit
 At5g01770 Recombinant
 At5g01770 Antibody
 T20L15.40 ELISA Kit
 T20L15.40 Recombinant
 T20L15.40 Antibody
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Proteins Root Name Listing
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