| Regulatory factor X-associated protein ELISA Kit|
Regulatory factor X-associated protein Recombinant
Regulatory factor X-associated protein Antibody
|Also known as Regulatory factor X-associated protein (RFX-associated protein). |
RFXAP: Part of the RFX complex that binds to the X-box of MHC II promoters. Defects in RFXAP are a cause of bare lymphocyte syndrome type 2 (BLS2); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset.
It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
Protein type: DNA-binding
Cellular Component: nucleus
Molecular Function: DNA binding; transcription coactivator activity
Biological Process: positive regulation of transcription, DNA-dependent
| Rfxap ELISA Kit|