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Retinoblastoma-binding protein

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As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.

Below are the list of possible Retinoblastoma-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Retinoblastoma-binding protein 5

 Retinoblastoma-binding protein 5 ELISA Kit
 Retinoblastoma-binding protein 5 Recombinant
 Retinoblastoma-binding protein 5 Antibody
Also known as Retinoblastoma-binding protein 5 (RBBP-5).
RBBP5: As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP
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1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: histone methyltransferase complex; nucleolus; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); methylated histone residue binding; protein binding

Biological Process: histone H3-K4 methylation; response to DNA damage stimulus; response to estrogen stimulus
 Rbbp5 ELISA Kit
 Rbbp5 Recombinant
 Rbbp5 Antibody
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Retinoblastoma-binding protein 5 homolog

 Retinoblastoma-binding protein 5 homolog ELISA Kit
 Retinoblastoma-binding protein 5 homolog Recombinant
 Retinoblastoma-binding protein 5 homolog Antibody
Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.
 Rbbp5 ELISA Kit
 Rbbp5 Recombinant
 Rbbp5 Antibody
 CG5585 ELISA Kit
 CG5585 Recombinant
 CG5585 Antibody
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Retinoblastoma-binding protein homolog 5

 Retinoblastoma-binding protein homolog 5 ELISA Kit
 Retinoblastoma-binding protein homolog 5 Recombinant
 Retinoblastoma-binding protein homolog 5 Antibody
Required for di- and trimethylation at 'Lys-4' of histone H3.
 rbbp-5 ELISA Kit
 rbbp-5 Recombinant
 rbbp-5 Antibody
 F21H12.1 ELISA Kit
 F21H12.1 Recombinant
 F21H12.1 Antibody
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