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Rho guanine nucleotide exchange factor

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Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Below are the list of possible Rho guanine nucleotide exchange factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Rho guanine nucleotide exchange factor 1

 Rho guanine nucleotide exchange factor 1 ELISA Kit
 Rho guanine nucleotide exchange factor 1 Recombinant
 Rho guanine nucleotide exchange factor 1 Antibody
Also known as Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5).
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alt
>>>
ernatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
 ARHGEF1 ELISA Kit
 ARHGEF1 Recombinant
 ARHGEF1 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 10

 Rho guanine nucleotide exchange factor 10 ELISA Kit
 Rho guanine nucleotide exchange factor 10 Recombinant
 Rho guanine nucleotide exchange factor 10 Antibody
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alter
>>>
native splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome

Molecular Function: kinesin binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: centrosome duplication; myelination in the peripheral nervous system; positive regulation of stress fiber formation

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
 ARHGEF10 ELISA Kit
 ARHGEF10 Recombinant
 ARHGEF10 Antibody
 KIAA0294 ELISA Kit
 KIAA0294 Recombinant
 KIAA0294 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 11

 Rho guanine nucleotide exchange factor 11 ELISA Kit
 Rho guanine nucleotide exchange factor 11 Recombinant
 Rho guanine nucleotide exchange factor 11 Antibody
Also known as Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).
ARHGEF11: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splici
>>>
ng.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol; intracellular

Molecular Function: G-protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
 ARHGEF11 ELISA Kit
 ARHGEF11 Recombinant
 ARHGEF11 Antibody
 KIAA0380 ELISA Kit
 KIAA0380 Recombinant
 KIAA0380 Antibody
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Rho guanine nucleotide exchange factor 12

 Rho guanine nucleotide exchange factor 12 ELISA Kit
 Rho guanine nucleotide exchange factor 12 Recombinant
 Rho guanine nucleotide exchange factor 12 Antibody
Also known as Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Cellular Component: cytoplasm

Molecular Function: G-protein-coupled receptor binding; protein bin
>>>
ding

Biological Process: G-protein coupled receptor protein signaling pathway
 Arhgef12 ELISA Kit
 Arhgef12 Recombinant
 Arhgef12 Antibody
 Kiaa0382 ELISA Kit
 Kiaa0382 Recombinant
 Kiaa0382 Antibody
 Larg ELISA Kit
 Larg Recombinant
 Larg Antibody
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Rho guanine nucleotide exchange factor 15

 Rho guanine nucleotide exchange factor 15 ELISA Kit
 Rho guanine nucleotide exchange factor 15 Recombinant
 Rho guanine nucleotide exchange factor 15 Antibody
Also known as Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5).
ephexin-5: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

Protein type: GEFs; GEFs, Rac/Rho

Cellular Component: cytoplasm; dendrite >>>
r>
Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of stress fiber formation; regulation of catalytic activity
 Arhgef15 ELISA Kit
 Arhgef15 Recombinant
 Arhgef15 Antibody
 Kiaa0915 ELISA Kit
 Kiaa0915 Recombinant
 Kiaa0915 Antibody
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Rho guanine nucleotide exchange factor 16

 Rho guanine nucleotide exchange factor 16 ELISA Kit
 Rho guanine nucleotide exchange factor 16 Recombinant
 Rho guanine nucleotide exchange factor 16 Antibody
Also known as Rho guanine nucleotide exchange factor 16 (Ephexin-4).
ARHGEF16: a Rho guanine exchange factor protein that contains 1 DH, 1 PH and 1 SH3 domain.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Cellular Component: cell-cell adherens junction

Molecular Function: PDZ domain binding; receptor tyrosine kinase binding; Rho GTPase binding; Rho guanyl
>>>
-nucleotide exchange factor activity
 Arhgef16 ELISA Kit
 Arhgef16 Recombinant
 Arhgef16 Antibody
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Rho guanine nucleotide exchange factor 17

 Rho guanine nucleotide exchange factor 17 ELISA Kit
 Rho guanine nucleotide exchange factor 17 Recombinant
 Rho guanine nucleotide exchange factor 17 Antibody
ARHGEF17: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.

Protein type: GEFs; GEFs, Rac/Rho

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton organization and biogenesis
 Arhgef17 ELISA Kit
 Arhgef17 Recombinant
 Arhgef17 Antibody
 Kiaa0337 ELISA Kit
 Kiaa0337 Recombinant
 Kiaa0337 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 18

 Rho guanine nucleotide exchange factor 18 ELISA Kit
 Rho guanine nucleotide exchange factor 18 Recombinant
 Rho guanine nucleotide exchange factor 18 Antibody
ARHGEF18: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G prot
>>>
eins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; cytoplasm

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton organization and biogenesis; regulation of cell shape; small GTPase mediated signal transduction
 Arhgef18 ELISA Kit
 Arhgef18 Recombinant
 Arhgef18 Antibody
 Kiaa0521 ELISA Kit
 Kiaa0521 Recombinant
 Kiaa0521 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 19

 Rho guanine nucleotide exchange factor 19 ELISA Kit
 Rho guanine nucleotide exchange factor 19 Recombinant
 Rho guanine nucleotide exchange factor 19 Antibody
Also known as Rho guanine nucleotide exchange factor 19 (Ephexin-2).
ARHGEF19: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 1p36.13

Molecular Function: protein binding

Biological Process: regulation of ac
>>>
tin cytoskeleton organization and biogenesis
 ARHGEF19 ELISA Kit
 ARHGEF19 Recombinant
 ARHGEF19 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 2

 Rho guanine nucleotide exchange factor 2 ELISA Kit
 Rho guanine nucleotide exchange factor 2 Recombinant
 Rho guanine nucleotide exchange factor 2 Antibody
Also known as Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1).
ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemo
>>>
taxis
 ARHGEF2 ELISA Kit
 ARHGEF2 Recombinant
 ARHGEF2 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 25

 Rho guanine nucleotide exchange factor 25 ELISA Kit
 Rho guanine nucleotide exchange factor 25 Recombinant
 Rho guanine nucleotide exchange factor 25 Antibody
Also known as Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT).
GEFT: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho fami
>>>
ly of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Cellular Component: myofibril; plasma membrane
 Arhgef25 ELISA Kit
 Arhgef25 Recombinant
 Arhgef25 Antibody
 Geft ELISA Kit
 Geft Recombinant
 Geft Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 26

 Rho guanine nucleotide exchange factor 26 ELISA Kit
 Rho guanine nucleotide exchange factor 26 Recombinant
 Rho guanine nucleotide exchange factor 26 Antibody
Also known as Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor).
SGEF: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

>>>
Chromosomal Location of Human Ortholog: 3q25.2
 ARHGEF26 ELISA Kit
 ARHGEF26 Recombinant
 ARHGEF26 Antibody
 SGEF ELISA Kit
 SGEF Recombinant
 SGEF Antibody
 HMFN1864 ELISA Kit
 HMFN1864 Recombinant
 HMFN1864 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 28

 Rho guanine nucleotide exchange factor 28 ELISA Kit
 Rho guanine nucleotide exchange factor 28 Recombinant
 Rho guanine nucleotide exchange factor 28 Antibody
Also known as Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor).
RGNEF: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogene
>>>
sis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Molecular Function: guanyl-nucleotide exchange factor activity

Biological Process: central nervous system neuron axonogenesis; neurofilament cytoskeleton organization and biogenesis
 Arhgef28 ELISA Kit
 Arhgef28 Recombinant
 Arhgef28 Antibody
 Rgnef ELISA Kit
 Rgnef Recombinant
 Rgnef Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 3

 Rho guanine nucleotide exchange factor 3 ELISA Kit
 Rho guanine nucleotide exchange factor 3 Recombinant
 Rho guanine nucleotide exchange factor 3 Antibody
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
 ARHGEF3 ELISA Kit
 ARHGEF3 Recombinant
 ARHGEF3 Antibody
 QccE-16434 ELISA Kit
 QccE-16434 Recombinant
 QccE-16434 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 33

 Rho guanine nucleotide exchange factor 33 ELISA Kit
 Rho guanine nucleotide exchange factor 33 Recombinant
 Rho guanine nucleotide exchange factor 33 Antibody
ARHGEF33: May act as a guanine-nucleotide releasing factor.

Protein type: GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 2p22.1
 ARHGEF33 ELISA Kit
 ARHGEF33 Recombinant
 ARHGEF33 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 35

 Rho guanine nucleotide exchange factor 35 ELISA Kit
 Rho guanine nucleotide exchange factor 35 Recombinant
 Rho guanine nucleotide exchange factor 35 Antibody
Also known as Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein).
ARHGEF35:

Chromosomal Location of Human Ortholog: 7q35
 ARHGEF35 ELISA Kit
 ARHGEF35 Recombinant
 ARHGEF35 Antibody
 ARHGEF5L ELISA Kit
 ARHGEF5L Recombinant
 ARHGEF5L Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 37

 Rho guanine nucleotide exchange factor 37 ELISA Kit
 Rho guanine nucleotide exchange factor 37 Recombinant
 Rho guanine nucleotide exchange factor 37 Antibody
ARHGEF37: May act as a guanine nucleotide exchange factor (GEF).

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 5q32

Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of GTPase activity; small GTPase mediated signal transduction
 ARHGEF37 ELISA Kit
 ARHGEF37 Recombinant
 ARHGEF37 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 38

 Rho guanine nucleotide exchange factor 38 ELISA Kit
 Rho guanine nucleotide exchange factor 38 Recombinant
 Rho guanine nucleotide exchange factor 38 Antibody
ARHGEF38: May act as a guanine-nucleotide releasing factor.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 4q24

Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of GTPase activity; small GTPase mediated signal transduction
 ARHGEF38 ELISA Kit
 ARHGEF38 Recombinant
 ARHGEF38 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 39

 Rho guanine nucleotide exchange factor 39 ELISA Kit
 Rho guanine nucleotide exchange factor 39 Recombinant
 Rho guanine nucleotide exchange factor 39 Antibody
ARHGEF39: Guanine nucleotide exchange factor. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Cellular Component: plasma membrane

Biological Process: positive regulation of cell migration
 Arhgef39 ELISA Kit
 Arhgef39 Recombinant
 Arhgef39 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 4

 Rho guanine nucleotide exchange factor 4 ELISA Kit
 Rho guanine nucleotide exchange factor 4 Recombinant
 Rho guanine nucleotide exchange factor 4 Antibody
Also known as Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1).
ARHGEF4: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP
>>>
9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q22

Cellular Component: cytosol

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: filopodium formation; lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction
 ARHGEF4 ELISA Kit
 ARHGEF4 Recombinant
 ARHGEF4 Antibody
 KIAA1112 ELISA Kit
 KIAA1112 Recombinant
 KIAA1112 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 40

 Rho guanine nucleotide exchange factor 40 ELISA Kit
 Rho guanine nucleotide exchange factor 40 Recombinant
 Rho guanine nucleotide exchange factor 40 Antibody
Also known as Rho guanine nucleotide exchange factor 40 (Protein SOLO).
SOLO: has similarities to a guanine nucleotide exchange factor for RhoA (ARHA2) that can induce cellular transformation.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 14q11.2
 ARHGEF40 ELISA Kit
 ARHGEF40 Recombinant
 ARHGEF40 Antibody
 SOLO ELISA Kit
 SOLO Recombinant
 SOLO Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 5

 Rho guanine nucleotide exchange factor 5 ELISA Kit
 Rho guanine nucleotide exchange factor 5 Recombinant
 Rho guanine nucleotide exchange factor 5 Antibody
ARHGEF5: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding

Biological Process: actin cytoskeleton organization and biogenesis;
>>>
myeloid dendritic cell chemotaxis; positive regulation of GTPase activity; positive regulation of JNK activity; positive regulation of stress fiber formation; positive regulation of transcription factor activity; regulation of actin cytoskeleton organization and biogenesis; regulation of cytoskeleton organization and biogenesis; regulation of GTPase activity
 Arhgef5 ELISA Kit
 Arhgef5 Recombinant
 Arhgef5 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 6

 Rho guanine nucleotide exchange factor 6 ELISA Kit
 Rho guanine nucleotide exchange factor 6 Recombinant
 Rho guanine nucleotide exchange factor 6 Antibody
Also known as Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6).
ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq26.3

Cell
>>>
ular Component: cytosol; intracellular; lamellipodium

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction

Disease: Mental Retardation, X-linked 46
 ARHGEF6 ELISA Kit
 ARHGEF6 Recombinant
 ARHGEF6 Antibody
 COOL2 ELISA Kit
 COOL2 Recombinant
 COOL2 Antibody
 KIAA0006 ELISA Kit
 KIAA0006 Recombinant
 KIAA0006 Antibody
 PIXA ELISA Kit
 PIXA Recombinant
 PIXA Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 7

 Rho guanine nucleotide exchange factor 7 ELISA Kit
 Rho guanine nucleotide exchange factor 7 Recombinant
 Rho guanine nucleotide exchange factor 7 Antibody
Also known as Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85).
ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling
>>>
by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; protein complex

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
 ARHGEF7 ELISA Kit
 ARHGEF7 Recombinant
 ARHGEF7 Antibody
 COOL1 ELISA Kit
 COOL1 Recombinant
 COOL1 Antibody
 KIAA0142 ELISA Kit
 KIAA0142 Recombinant
 KIAA0142 Antibody
 P85SPR ELISA Kit
 P85SPR Recombinant
 P85SPR Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 8

 Rho guanine nucleotide exchange factor 8 ELISA Kit
 Rho guanine nucleotide exchange factor 8 Recombinant
 Rho guanine nucleotide exchange factor 8 Antibody
Also known as Rho guanine nucleotide exchange factor 8 (AtRopGEF8) (Rho of plants guanine nucleotide exchange factor 8).
Encodes a member of KPP-like gene family, homolog of KPP (kinase partner protein) gene in tomato. Also a member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily.
 ROPGEF8 ELISA Kit
 ROPGEF8 Recombinant
 ROPGEF8 Antibody
 At3g24620 ELISA Kit
 At3g24620 Recombinant
 At3g24620 Antibody
 MOB24.21 ELISA Kit
 MOB24.21 Recombinant
 MOB24.21 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor 9

 Rho guanine nucleotide exchange factor 9 ELISA Kit
 Rho guanine nucleotide exchange factor 9 Recombinant
 Rho guanine nucleotide exchange factor 9 Antibody
Also known as Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9).
ARHGEF9: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8). A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation
>>>
or extreme emotion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: Xq11.1

Cellular Component: cytoplasm; cytosol

Molecular Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction

Disease: Epileptic Encephalopathy, Early Infantile, 8
 ARHGEF9 ELISA Kit
 ARHGEF9 Recombinant
 ARHGEF9 Antibody
 ARHDH9 ELISA Kit
 ARHDH9 Recombinant
 ARHDH9 Antibody
 KIAA0424 ELISA Kit
 KIAA0424 Recombinant
 KIAA0424 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor gef1

 Rho guanine nucleotide exchange factor gef1 ELISA Kit
 Rho guanine nucleotide exchange factor gef1 Recombinant
 Rho guanine nucleotide exchange factor gef1 Antibody
Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.
 gef1 ELISA Kit
 gef1 Recombinant
 gef1 Antibody
 SPAC24H6.09 ELISA Kit
 SPAC24H6.09 Recombinant
 SPAC24H6.09 Antibody
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Rho guanine nucleotide exchange factor gef2

 Rho guanine nucleotide exchange factor gef2 ELISA Kit
 Rho guanine nucleotide exchange factor gef2 Recombinant
 Rho guanine nucleotide exchange factor gef2 Antibody
Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.
 gef2 ELISA Kit
 gef2 Recombinant
 gef2 Antibody
 SPAC31A2.16 ELISA Kit
 SPAC31A2.16 Recombinant
 SPAC31A2.16 Antibody
Table BarTOPTable Bar
 

Rho guanine nucleotide exchange factor gef3

 Rho guanine nucleotide exchange factor gef3 ELISA Kit
 Rho guanine nucleotide exchange factor gef3 Recombinant
 Rho guanine nucleotide exchange factor gef3 Antibody
Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.
 gef3 ELISA Kit
 gef3 Recombinant
 gef3 Antibody
 SPBC29A3.17 ELISA Kit
 SPBC29A3.17 Recombinant
 SPBC29A3.17 Antibody
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Rho guanine nucleotide exchange factor osg-1

 Rho guanine nucleotide exchange factor osg-1 ELISA Kit
 Rho guanine nucleotide exchange factor osg-1 Recombinant
 Rho guanine nucleotide exchange factor osg-1 Antibody
Also known as Rho guanine nucleotide exchange factor osg-1 (Oxidative stress-susceptible GEF1).
Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress.
 osg-1 ELISA Kit
 osg-1 Recombinant
 osg-1 Antibody
 R02F2.2/R02F2.3 ELISA Kit
 R02F2.2/R02F2.3 Recombinant
 R02F2.2/R02F2.3 Antibody
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Rho guanine nucleotide exchange factor scd1

 Rho guanine nucleotide exchange factor scd1 ELISA Kit
 Rho guanine nucleotide exchange factor scd1 Recombinant
 Rho guanine nucleotide exchange factor scd1 Antibody
Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes.
 scd1 ELISA Kit
 scd1 Recombinant
 scd1 Antibody
 ral1 ELISA Kit
 ral1 Recombinant
 ral1 Antibody
 SPAC16E8.09 ELISA Kit
 SPAC16E8.09 Recombinant
 SPAC16E8.09 Antibody
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