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Ribosome-binding protein

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

Below are the list of possible Ribosome-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Ribosome-binding protein 1

 Ribosome-binding protein 1 ELISA Kit
 Ribosome-binding protein 1 Recombinant
 Ribosome-binding protein 1 Antibody
Also known as Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein).
RRBP1: a single-pass type III membrane protein of the rough endoplasmic reticulum membrane. Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Associated with the unfolded protein response (UPR) an
d has anti-apoptotic activity. Knockdown of RRBP1 induces ER stress, and is associated with a significant reduction in the expression of glucose-regulated protein 78 (GRP78). GRP78 regulates the UPR, is widely upregulated in cancer, and plays an important role in chemotherapy resistance in some cancers. Upregulated in many cancers: overexpressed in a high proportion of breast carcinoma cases tested, and is highly expressed in lung cancer tissue compared with adjacent normal tissues. Because RRBP1 appears to play a role in tumor cell survival, it may be a candidate for new targeted therapeutics. Three human isoforms are produced by alternative splicing.

Protein type: Membrane protein, integral; Ribosomal; Translation

Chromosomal Location of Human Ortholog: 20p12

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane; membrane; ribosome

Molecular Function: receptor activity

Biological Process: osteoblast differentiation; translation
 RRBP1 Recombinant
 RRBP1 Antibody
 KIAA1398 Recombinant
 KIAA1398 Antibody
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