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Roundabout

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Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development .

Below are the list of possible Roundabout products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Roundabout homolog 1

 Roundabout homolog 1 ELISA Kit
 Roundabout homolog 1 Recombinant
 Roundabout homolog 1 Antibody
ROBO1: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required fo
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r lung development. Belongs to the immunoglobulin superfamily. ROBO family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: axolemma; axon; cell soma; cell surface; cytoplasm

Molecular Function: axon guidance receptor activity; identical protein binding; LRR domain binding; protein binding

Biological Process: axon guidance; axon midline choice point recognition; caspase activation; cell migration during sprouting angiogenesis; chemorepulsion involved in postnatal olfactory bulb interneuron migration; heart development; homophilic cell adhesion; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of mammary gland epithelial cell proliferation; negative regulation of negative chemotaxis; olfactory bulb interneuron development; positive regulation of axonogenesis; positive regulation of Rho protein signal transduction; regulation of dendrite morphogenesis
 Robo1 ELISA Kit
 Robo1 Recombinant
 Robo1 Antibody
 Dutt1 ELISA Kit
 Dutt1 Recombinant
 Dutt1 Antibody
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Roundabout homolog 2

 Roundabout homolog 2 ELISA Kit
 Roundabout homolog 2 Recombinant
 Roundabout homolog 2 Antibody
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine fro
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m the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
 ROBO2 ELISA Kit
 ROBO2 Recombinant
 ROBO2 Antibody
 KIAA1568 ELISA Kit
 KIAA1568 Recombinant
 KIAA1568 Antibody
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Roundabout homolog 3

 Roundabout homolog 3 ELISA Kit
 Roundabout homolog 3 Recombinant
 Roundabout homolog 3 Antibody
Also known as Roundabout homolog 3 (Retinoblastoma-inhibiting gene 1 protein) (Rig-1).
ROBO3: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for
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hindbrain axon midline crossing. Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS). Patients show a medulla where motor and sensory projections appear uncrossed. Belongs to the immunoglobulin superfamily. ROBO family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: axon

Molecular Function: protein binding

Biological Process: axon guidance; axon midline choice point recognition; neuron migration
 Robo3 ELISA Kit
 Robo3 Recombinant
 Robo3 Antibody
 Rbig1 ELISA Kit
 Rbig1 Recombinant
 Rbig1 Antibody
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Roundabout homolog 4

 Roundabout homolog 4 ELISA Kit
 Roundabout homolog 4 Recombinant
 Roundabout homolog 4 Antibody
ROBO4: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Belongs to the immunoglobulin superfamily. ROBO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellula
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r Component: external side of plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity

Biological Process: angiogenesis; negative regulation of cell migration; regulation of apoptosis
 Robo4 ELISA Kit
 Robo4 Recombinant
 Robo4 Antibody
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