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rRNA 2'-O-methyltransferase fibrillarin

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S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .

Below are the list of possible rRNA 2'-O-methyltransferase fibrillarin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

rRNA 2'-O-methyltransferase fibrillarin

 rRNA 2'-O-methyltransferase fibrillarin ELISA Kit
 rRNA 2'-O-methyltransferase fibrillarin Recombinant
 rRNA 2'-O-methyltransferase fibrillarin Antibody
Also known as rRNA 2'-O-methyltransferase fibrillarin (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase).
FBL: Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Interacts with NOLC1. Component of box C/D small nucleolar ribonucleoprotein (snoRNP) part
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icles that contain NHP2L1, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Y small nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20. Interacts with DDX5. Belongs to the methyltransferase superfamily. Fibrillarin family.

Protein type: EC 2.1.1.-; Methyltransferase; Nucleolus; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: Cajal body; membrane; nucleolus; nucleoplasm; nucleus; small subunit processome

Molecular Function: ATPase binding; protein binding; RNA binding; rRNA methyltransferase activity

Biological Process: box C/D snoRNA 3'-end processing; osteoblast differentiation; rRNA methylation; rRNA processing; snoRNA localization
 FBL ELISA Kit
 FBL Recombinant
 FBL Antibody
 FIB1 ELISA Kit
 FIB1 Recombinant
 FIB1 Antibody
 FLRN ELISA Kit
 FLRN Recombinant
 FLRN Antibody
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