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Runt-related transcription factor

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CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells.

Below are the list of possible Runt-related transcription factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Runt-related transcription factor 1

 Runt-related transcription factor 1 ELISA Kit
 Runt-related transcription factor 1 Recombinant
 Runt-related transcription factor 1 Antibody
Also known as Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B).
AML1: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivatio
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n activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and ALYREF/THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1. Interacts with YAP1. Interacts with HIPK2. Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity. Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Cellular Component: basement membrane; cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: calcium ion binding; DNA binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity; transcription factor binding

Biological Process: behavioral response to pain; central nervous system development; chondrocyte differentiation; embryonic hemopoiesis; hair follicle morphogenesis; hemopoiesis; in utero embryonic development; liver development; myeloid cell differentiation; myeloid progenitor cell differentiation; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of transcription, DNA-dependent; neuron development; neuron differentiation; neuron fate commitment; ossification; ovulation; positive regulation of angiogenesis; positive regulation of granulocyte differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cell differentiation; regulation of signal transduction; regulation of T cell anergy; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to denervation involved in regulation of muscle adaptation; response to retinoic acid; skeletal development
 Runx1 ELISA Kit
 Runx1 Recombinant
 Runx1 Antibody
 Aml1 ELISA Kit
 Aml1 Recombinant
 Aml1 Antibody
 Cbfa2 ELISA Kit
 Cbfa2 Recombinant
 Cbfa2 Antibody
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Runt-related transcription factor 2

 Runt-related transcription factor 2 ELISA Kit
 Runt-related transcription factor 2 Recombinant
 Runt-related transcription factor 2 Antibody
Also known as Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit).
AML3: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the
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core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation. Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors. Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 and HIPK3. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with KAT6A and KAT6B. Binds to cyclin B1 CCNB1. Interacts with DDX5. Specifically expressed in osteoblasts. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nuclear chromatin; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: BMP signaling pathway; chondrocyte differentiation; hemopoiesis; negative regulation of transcription, DNA-dependent; neuron differentiation; ossification; osteoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of cell differentiation; regulation of transcription from RNA polymerase II promoter

Disease: Cleidocranial Dysplasia; Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly
 RUNX2 ELISA Kit
 RUNX2 Recombinant
 RUNX2 Antibody
 AML3 ELISA Kit
 AML3 Recombinant
 AML3 Antibody
 CBFA1 ELISA Kit
 CBFA1 Recombinant
 CBFA1 Antibody
 OSF2 ELISA Kit
 OSF2 Recombinant
 OSF2 Antibody
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Runt-related transcription factor 3

 Runt-related transcription factor 3 ELISA Kit
 Runt-related transcription factor 3 Recombinant
 Runt-related transcription factor 3 Antibody
Also known as Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).
AML2: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subuni
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t binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytoplasm; nuclear chromatin; nucleus

Molecular Function: DNA binding; histone deacetylase binding; protein binding; SMAD binding

Biological Process: axon guidance; cell maturation; chondrocyte differentiation; hair follicle morphogenesis; hemopoiesis; interferon-gamma production; mRNA transcription from RNA polymerase II promoter; negative regulation of cell cycle; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neurite development; ossification; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cell differentiation
 Runx3 ELISA Kit
 Runx3 Recombinant
 Runx3 Antibody
 Aml2 ELISA Kit
 Aml2 Recombinant
 Aml2 Antibody
 Cbfa3 ELISA Kit
 Cbfa3 Recombinant
 Cbfa3 Antibody
 Pebp2a3 ELISA Kit
 Pebp2a3 Recombinant
 Pebp2a3 Antibody
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