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Sal-like protein

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Transcriptional repressor involved in organogenesis.

Below are the list of possible Sal-like protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sal-like protein 1

 Sal-like protein 1 ELISA Kit
 Sal-like protein 1 Recombinant
 Sal-like protein 1 Antibody
Also known as Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1).
SALL1: Transcriptional repressor involved in organogenesis. Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS). TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss. Some individuals with SALL1 mutations manifest a phenotype overlapping with TBS and bronchio-oto-renal syndrome. Clinica
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l features include dysplastic ears, hypoplastic kidneys with impaired renal function, gastroesophageal reflux, hypermetropia, hypospadias, and mild developmental delay. Affected individuals lack the characteristic anal or hand malformations of TBS. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: chromocenter; cytoplasm; heterochromatin; nucleoplasm; nucleus; NuRD complex

Molecular Function: beta-catenin binding; histone deacetylase activity; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: adrenal gland development; embryonic digit morphogenesis; embryonic gut development; gonad development; heart development; inductive cell-cell signaling; kidney development; limb development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neurogenesis; olfactory bulb interneuron differentiation; olfactory nerve development; outer ear morphogenesis; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; somatic stem cell maintenance; ureteric bud branching; ureteric bud development

Disease: Townes-brocks Syndrome
 SALL1 ELISA Kit
 SALL1 Recombinant
 SALL1 Antibody
 SAL1 ELISA Kit
 SAL1 Recombinant
 SAL1 Antibody
 ZNF794 ELISA Kit
 ZNF794 Recombinant
 ZNF794 Antibody
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Sal-like protein 2

 Sal-like protein 2 ELISA Kit
 Sal-like protein 2 Recombinant
 Sal-like protein 2 Antibody
Also known as Sal-like protein 2 (Spalt-like protein 2) (Zinc finger protein Spalt-2) (Sal-2) (mSal-2).
SALL2: Probable transcription factor. Belongs to the sal C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein

Cellular Component: NuRD complex

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological P
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rocess: eye development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural tube development; signal transduction
 Sall2 ELISA Kit
 Sall2 Recombinant
 Sall2 Antibody
 Sal2 ELISA Kit
 Sal2 Recombinant
 Sal2 Antibody
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Sal-like protein 3

 Sal-like protein 3 ELISA Kit
 Sal-like protein 3 Recombinant
 Sal-like protein 3 Antibody
Also known as Sal-like protein 3 (MSal) (Spalt-like protein 3).
SALL3: Probable transcription factor. Belongs to the sal C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Motility/polarity/chemotaxis

Cellular Component: nucleus

Molecular Function: sequence-specific DNA bin
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ding; transcription factor activity

Biological Process: forelimb morphogenesis; hindlimb morphogenesis; negative regulation of smoothened signaling pathway; olfactory bulb interneuron development; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
 Sall3 ELISA Kit
 Sall3 Recombinant
 Sall3 Antibody
 Sal ELISA Kit
 Sal Recombinant
 Sal Antibody
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Sal-like protein 4

 Sal-like protein 4 ELISA Kit
 Sal-like protein 4 Recombinant
 Sal-like protein 4 Antibody
Also known as Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4).
SALL4: a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a ro
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le in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: multicellular organismal development; regulation of transcription, DNA-dependent; signal transduction; somatic stem cell maintenance; transcription from RNA polymerase II promoter

Disease: Duane-radial Ray Syndrome; Ivic Syndrome
 SALL4 ELISA Kit
 SALL4 Recombinant
 SALL4 Antibody
 ZNF797 ELISA Kit
 ZNF797 Recombinant
 ZNF797 Antibody
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