| Segment polarity protein dishevelled homolog mig-5 ELISA Kit|
Segment polarity protein dishevelled homolog mig-5 Recombinant
Segment polarity protein dishevelled homolog mig-5 Antibody
|Also known as Segment polarity protein dishevelled homolog mig-5 (Abnormal cell migration protein 5). |
Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:26795562). Functions redundantly with other dishevelled family members throughout development (PubMed:19298786, PubMed:25344071, PubMed:26460008, PubMed:26795562). During embryonic and larval development, co
ntrols cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells (PubMed:16899238, PubMed:26795562). In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the correct mitotic spindle orientation of the ABar blastomere division plane (PubMed:16899238, PubMed:25344071). Controls the polarity and the asymmetric localization of downstream components of the wnt/beta-catenin asymmetry pathway, and in particular, controls the asymmetric localization of the wnt receptor lin-17/Frizzled in ectodermal blast B cells (PubMed:16631156, PubMed:17196955, PubMed:19298786, PubMed:26795562). May act redundantly with dsh-2 to regulate the expression and nuclear localization of the beta-catenin homolog wrm-2, but alone seems to be required for the polarity of wrm-2 during the asymmetric cell division of hypodermal seam cells (PubMed:26795562). Also, maintains the polarity and migration of QL neuroblasts in larvae (PubMed:16899238). During the embryonic development of touch receptor neurons, may act redundantly with dsh-1, downstream of wnt signaling ligands and the wnt receptor lin-17/Frizzled, to direct the growth of neurites of touch receptor neurons towards the anterior of the body of the worm and towards the PLM touch receptor neuron and other tail neurons (PubMed:26460008). May play a role in the guidance of posterior D-type motor neuron axons along the anteroposterior axis (PubMed:19259273).
| mig-5 ELISA Kit|
| T05C12.6 ELISA Kit|