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Segment polarity protein dishevelled

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Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.

Below are the list of possible Segment polarity protein dishevelled products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Segment polarity protein dishevelled

 Segment polarity protein dishevelled ELISA Kit
 Segment polarity protein dishevelled Recombinant
 Segment polarity protein dishevelled Antibody
Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity.
 dsh ELISA Kit
 dsh Recombinant
 dsh Antibody
 CG18361 ELISA Kit
 CG18361 Recombinant
 CG18361 Antibody
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Segment polarity protein dishevelled homolog DVL-1

 Segment polarity protein dishevelled homolog DVL-1 ELISA Kit
 Segment polarity protein dishevelled homolog DVL-1 Recombinant
 Segment polarity protein dishevelled homolog DVL-1 Antibody
Also known as Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).
DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt
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genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasmic vesicle; cytosol; growth cone; lateral plasma membrane; neuron projection; synapse

Molecular Function: enzyme binding; frizzled binding; identical protein binding; protein binding; protein kinase binding

Biological Process: dendrite morphogenesis; negative regulation of protein binding; negative regulation of protein kinase activity; neural tube development; neuromuscular junction development; neurotransmitter secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; protein stabilization; receptor clustering; regulation of neurotransmitter levels; synapse organization and biogenesis; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Robinow Syndrome, Autosomal Dominant; Robinow Syndrome, Autosomal Dominant 2
 DVL1 ELISA Kit
 DVL1 Recombinant
 DVL1 Antibody
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Segment polarity protein dishevelled homolog DVL-2

 Segment polarity protein dishevelled homolog DVL-2 ELISA Kit
 Segment polarity protein dishevelled homolog DVL-2 Recombinant
 Segment polarity protein dishevelled homolog DVL-2 Antibody
Also known as Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).
DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each c
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ontain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: apical part of cell; cell cortex; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytosol; lateral plasma membrane; nucleus; plasma membrane

Molecular Function: frizzled binding; protein binding; protein binding, bridging; protein domain specific binding; protein kinase binding; protein self-association; Rac GTPase binding

Biological Process: convergent extension involved in neural plate elongation; convergent extension involved in organogenesis; heart development; heart morphogenesis; neural tube closure; positive regulation of GTPase activity; positive regulation of JNK activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; protein oligomerization; segment specification; segmentation; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway
 Dvl2 ELISA Kit
 Dvl2 Recombinant
 Dvl2 Antibody
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Segment polarity protein dishevelled homolog DVL-3

 Segment polarity protein dishevelled homolog DVL-3 ELISA Kit
 Segment polarity protein dishevelled homolog DVL-3 Recombinant
 Segment polarity protein dishevelled homolog DVL-3 Antibody
Also known as Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).
May play a role in the signal transduction pathway mediated by multiple Wnt genes. Required in ciliogenesis for the docking of basal bodies to the apical plasma membrane.
 dvl3 ELISA Kit
 dvl3 Recombinant
 dvl3 Antibody
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Segment polarity protein dishevelled homolog mig-5

 Segment polarity protein dishevelled homolog mig-5 ELISA Kit
 Segment polarity protein dishevelled homolog mig-5 Recombinant
 Segment polarity protein dishevelled homolog mig-5 Antibody
Also known as Segment polarity protein dishevelled homolog mig-5 (Abnormal cell migration protein 5).
Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:26795562). Functions redundantly with other dishevelled family members throughout development (PubMed:19298786, PubMed:25344071, PubMed:26460008, PubMed:26795562). During embryonic and larval development, co
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ntrols cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells (PubMed:16899238, PubMed:26795562). In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the correct mitotic spindle orientation of the ABar blastomere division plane (PubMed:16899238, PubMed:25344071). Controls the polarity and the asymmetric localization of downstream components of the wnt/beta-catenin asymmetry pathway, and in particular, controls the asymmetric localization of the wnt receptor lin-17/Frizzled in ectodermal blast B cells (PubMed:16631156, PubMed:17196955, PubMed:19298786, PubMed:26795562). May act redundantly with dsh-2 to regulate the expression and nuclear localization of the beta-catenin homolog wrm-2, but alone seems to be required for the polarity of wrm-2 during the asymmetric cell division of hypodermal seam cells (PubMed:26795562). Also, maintains the polarity and migration of QL neuroblasts in larvae (PubMed:16899238). During the embryonic development of touch receptor neurons, may act redundantly with dsh-1, downstream of wnt signaling ligands and the wnt receptor lin-17/Frizzled, to direct the growth of neurites of touch receptor neurons towards the anterior of the body of the worm and towards the PLM touch receptor neuron and other tail neurons (PubMed:26460008). May play a role in the guidance of posterior D-type motor neuron axons along the anteroposterior axis (PubMed:19259273).
 mig-5 ELISA Kit
 mig-5 Recombinant
 mig-5 Antibody
 T05C12.6 ELISA Kit
 T05C12.6 Recombinant
 T05C12.6 Antibody
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