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Separin

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Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity).

Below are the list of possible Separin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Separin

 Separin ELISA Kit
 Separin Recombinant
 Separin Antibody
Also known as Separin (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase).
separase: a caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Regulated by at least two independent mechanisms. First, it is inactivated via its interaction with securin/PTTG1, which probably covers its active site. Second, phosphorylation inactivates it. It is completely phosphorylated during mitosis and de
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phosphorylated during anaphase. Two alternatively spliced isoforms have been described.

Protein type: EC 3.4.22.49; Protease

Cellular Component: centrosome; cytoplasm; nucleus

Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity

Biological Process: chromosome segregation; homologous chromosome segregation; meiosis I; meiotic chromosome separation; meiotic spindle organization and biogenesis; mitosis; mitotic sister chromatid segregation
 Espl1 ELISA Kit
 Espl1 Recombinant
 Espl1 Antibody
 Esp1 ELISA Kit
 Esp1 Recombinant
 Esp1 Antibody
 Kiaa0165 ELISA Kit
 Kiaa0165 Recombinant
 Kiaa0165 Antibody
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