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Serine/threonine-protein kinase greatwall

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Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Below are the list of possible Serine/threonine-protein kinase greatwall products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Serine/threonine-protein kinase greatwall

 Serine/threonine-protein kinase greatwall ELISA Kit
 Serine/threonine-protein kinase greatwall Recombinant
 Serine/threonine-protein kinase greatwall Antibody
Also known as Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L).
MASTL: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-del
>>>
ta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Defects in MASTL are the cause of thrombocytopenia type 2 (THC2). Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; MAST family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: centrosome; cleavage furrow; nucleoplasm; nucleus

Molecular Function: kinase activity; protein phosphatase 2A binding; protein serine/threonine kinase activity

Biological Process: G2/M transition of mitotic cell cycle; mitosis; negative regulation of protein phosphatase type 2A activity; peptidyl-serine phosphorylation; regulation of cell cycle; response to DNA damage stimulus

Disease: Thrombocytopenia 2
 MASTL ELISA Kit
 MASTL Recombinant
 MASTL Antibody
 GW ELISA Kit
 GW Recombinant
 GW Antibody
 GWL ELISA Kit
 GWL Recombinant
 GWL Antibody
 THC2 ELISA Kit
 THC2 Recombinant
 THC2 Antibody
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