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Serine/threonine-protein kinase tousled

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Below are the list of possible Serine/threonine-protein kinase tousled products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Serine/threonine-protein kinase tousled-like 1

 Serine/threonine-protein kinase tousled-like 1 ELISA Kit
 Serine/threonine-protein kinase tousled-like 1 Recombinant
 Serine/threonine-protein kinase tousled-like 1 Antibody
Also known as Serine/threonine-protein kinase tousled-like 1 (PKU-beta) (Tousled-like kinase 1).
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase.
The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
 TLK1 Recombinant
 TLK1 Antibody
 KIAA0137 Recombinant
 KIAA0137 Antibody
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Serine/threonine-protein kinase tousled-like 1-B

 Serine/threonine-protein kinase tousled-like 1-B ELISA Kit
 Serine/threonine-protein kinase tousled-like 1-B Recombinant
 Serine/threonine-protein kinase tousled-like 1-B Antibody
Also known as Serine/threonine-protein kinase tousled-like 1-B (PKU-beta) (Tousled-like kinase 1-B).
 tlk1b ELISA Kit
 tlk1b Recombinant
 tlk1b Antibody
 tlk1 ELISA Kit
 tlk1 Recombinant
 tlk1 Antibody
 wu:fe11e12 ELISA Kit
 wu:fe11e12 Recombinant
 wu:fe11e12 Antibody
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Serine/threonine-protein kinase tousled-like 2

 Serine/threonine-protein kinase tousled-like 2 ELISA Kit
 Serine/threonine-protein kinase tousled-like 2 Recombinant
 Serine/threonine-protein kinase tousled-like 2 Antibody
Also known as Serine/threonine-protein kinase tousled-like 2 (HsHPK) (PKU-alpha) (Tousled-like kinase 2).
TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated
degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); TLK family

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: cell junction; intermediate filament; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; protein binding; protein serine/threonine kinase activity

Biological Process: chromosome segregation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of chromatin assembly or disassembly; response to DNA damage stimulus
 TLK2 Recombinant
 TLK2 Antibody
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