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Serum paraoxonase/arylesterase

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Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Below are the list of possible Serum paraoxonase/arylesterase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Serum paraoxonase/arylesterase 1

 Serum paraoxonase/arylesterase 1 ELISA Kit
 Serum paraoxonase/arylesterase 1 Recombinant
 Serum paraoxonase/arylesterase 1 Antibody
Also known as Serum paraoxonase/arylesterase 1 (PON 1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1).
PON1: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low densi
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ty lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients. Belongs to the paraoxonase family.

Protein type: EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Hydrolase; Lipid-binding; Motility/polarity/chemotaxis; Phosphatase (non-protein); Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: extracellular space

Molecular Function: aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; phospholipid binding; protein homodimerization activity

Biological Process: aromatic compound catabolic process; carboxylic acid catabolic process; organophosphate catabolic process; phosphatidylcholine metabolic process; positive regulation of binding; positive regulation of transporter activity; response to toxin

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 5
 PON1 ELISA Kit
 PON1 Recombinant
 PON1 Antibody
 PON ELISA Kit
 PON Recombinant
 PON Antibody
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Serum paraoxonase/arylesterase 2

 Serum paraoxonase/arylesterase 2 ELISA Kit
 Serum paraoxonase/arylesterase 2 Recombinant
 Serum paraoxonase/arylesterase 2 Antibody
Also known as Serum paraoxonase/arylesterase 2 (PON 2) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2).
PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of M
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M-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.2; EC 3.1.1.81; Hydrolase; Motility/polarity/chemotaxis

Cellular Component: intracellular membrane-bound organelle; lysosome; mitochondrion; nucleus; plasma membrane

Molecular Function: arylesterase activity; identical protein binding

Biological Process: aromatic compound catabolic process; response to toxin
 Pon2 ELISA Kit
 Pon2 Recombinant
 Pon2 Antibody
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