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Sestrin

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May function as a negative feedback regulator of TOR function.

Below are the list of possible Sestrin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sestrin homolog

 Sestrin homolog ELISA Kit
 Sestrin homolog Recombinant
 Sestrin homolog Antibody
May function as a negative feedback regulator of TOR function.
 sesn-1 ELISA Kit
 sesn-1 Recombinant
 sesn-1 Antibody
 Y74C9A.5 ELISA Kit
 Y74C9A.5 Recombinant
 Y74C9A.5 Antibody
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Sestrin-1

 Sestrin-1 ELISA Kit
 Sestrin-1 Recombinant
 Sestrin-1 Antibody
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protecti
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on against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
 SESN1 ELISA Kit
 SESN1 Recombinant
 SESN1 Antibody
 QtsA-17454 ELISA Kit
 QtsA-17454 Recombinant
 QtsA-17454 Antibody
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Sestrin-2

 Sestrin-2 ELISA Kit
 Sestrin-2 Recombinant
 Sestrin-2 Antibody
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection
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against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
 SESN2 ELISA Kit
 SESN2 Recombinant
 SESN2 Antibody
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Sestrin-3

 Sestrin-3 ELISA Kit
 Sestrin-3 Recombinant
 Sestrin-3 Antibody
SESN3: a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alterna
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tive splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: cytoplasm
 SESN3 ELISA Kit
 SESN3 Recombinant
 SESN3 Antibody
 SEST3 ELISA Kit
 SEST3 Recombinant
 SEST3 Antibody
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