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SH2 domain-containing protein

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Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity).

Below are the list of possible SH2 domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

SH2 domain-containing protein 1A

 SH2 domain-containing protein 1A ELISA Kit
 SH2 domain-containing protein 1A Recombinant
 SH2 domain-containing protein 1A Antibody
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions,
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recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 ().
 SH2D1A ELISA Kit
 SH2D1A Recombinant
 SH2D1A Antibody
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SH2 domain-containing protein 1B

 SH2 domain-containing protein 1B ELISA Kit
 SH2 domain-containing protein 1B Recombinant
 SH2 domain-containing protein 1B Antibody
Also known as SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).
SH2D1B: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: intracellular

Molecular Function: phosphotyrosine binding; protein binding

Biological Process: leukocyte activation during immune response; natural killer cell inhibitory si
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gnaling pathway; negative regulation of interferon-gamma production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of innate immune response; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated immunity; positive regulation of peptidyl-tyrosine phosphorylation
 Sh2d1b ELISA Kit
 Sh2d1b Recombinant
 Sh2d1b Antibody
 Eat2 ELISA Kit
 Eat2 Recombinant
 Eat2 Antibody
 Eat2a ELISA Kit
 Eat2a Recombinant
 Eat2a Antibody
 Sh2d1b1 ELISA Kit
 Sh2d1b1 Recombinant
 Sh2d1b1 Antibody
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SH2 domain-containing protein 1B2

 SH2 domain-containing protein 1B2 ELISA Kit
 SH2 domain-containing protein 1B2 Recombinant
 SH2 domain-containing protein 1B2 Antibody
Also known as SH2 domain-containing protein 1B2 (EAT-2-related transducer) (ERT) (EAT-2B).
Sh2d1b2:

Protein type: Apoptosis

Molecular Function: protein binding

Biological Process: negative regulation of natural killer cell mediated cytotoxicity; peptidyl-tyrosine phosphorylation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of peptidyl-tyrosine phosphorylation; regulation of natural killer cell activation
 Sh2d1b2 ELISA Kit
 Sh2d1b2 Recombinant
 Sh2d1b2 Antibody
 Eat2b ELISA Kit
 Eat2b Recombinant
 Eat2b Antibody
 Sh2d1c ELISA Kit
 Sh2d1c Recombinant
 Sh2d1c Antibody
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SH2 domain-containing protein 2A

 SH2 domain-containing protein 2A ELISA Kit
 SH2 domain-containing protein 2A Recombinant
 SH2 domain-containing protein 2A Antibody
Also known as SH2 domain-containing protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk-binding protein) (Ribp).
TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis.

Protein type: Adaptor/scaffold

Molecular Function: SH3/SH2 adaptor activity

Biological Process: cell proliferation
 Sh2d2a ELISA Kit
 Sh2d2a Recombinant
 Sh2d2a Antibody
 Lad ELISA Kit
 Lad Recombinant
 Lad Antibody
 Ribp ELISA Kit
 Ribp Recombinant
 Ribp Antibody
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SH2 domain-containing protein 3A

 SH2 domain-containing protein 3A ELISA Kit
 SH2 domain-containing protein 3A Recombinant
 SH2 domain-containing protein 3A Antibody
Also known as SH2 domain-containing protein 3A (Novel SH2-containing protein 1).
SH2D3A: May play a role in JNK activation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.3

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: JNK cascade
 SH2D3A ELISA Kit
 SH2D3A Recombinant
 SH2D3A Antibody
 NSP1 ELISA Kit
 NSP1 Recombinant
 NSP1 Antibody
 UNQ175/PRO201 ELISA Kit
 UNQ175/PRO201 Recombinant
 UNQ175/PRO201 Antibody
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SH2 domain-containing protein 3C

 SH2 domain-containing protein 3C ELISA Kit
 SH2 domain-containing protein 3C Recombinant
 SH2 domain-containing protein 3C Antibody
Also known as SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (SH2 domain-containing Eph receptor-binding protein 1).
SHEP1: an adaptor protein linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. Directly links activated, tyrosine-phosphorylated Eph receptors to small Ras superfamily GTPases. Positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.

Protein type: Adaptor/scaffold

Molecular Function: SH3/SH2 adaptor activity; transmembrane receptor
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protein tyrosine kinase adaptor protein activity

Biological Process: JNK cascade; signal transduction
 Sh2d3c ELISA Kit
 Sh2d3c Recombinant
 Sh2d3c Antibody
 Chat ELISA Kit
 Chat Recombinant
 Chat Antibody
 Shep1 ELISA Kit
 Shep1 Recombinant
 Shep1 Antibody
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SH2 domain-containing protein 4A

 SH2 domain-containing protein 4A ELISA Kit
 SH2 domain-containing protein 4A Recombinant
 SH2 domain-containing protein 4A Antibody
SH2D4A: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: cytoplasm

Molecular Fu
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nction: phosphatase binding
 Sh2d4a ELISA Kit
 Sh2d4a Recombinant
 Sh2d4a Antibody
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SH2 domain-containing protein 4B

 SH2 domain-containing protein 4B ELISA Kit
 SH2 domain-containing protein 4B Recombinant
 SH2 domain-containing protein 4B Antibody
SH2D4B: 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 10q23.1
 SH2D4B ELISA Kit
 SH2D4B Recombinant
 SH2D4B Antibody
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SH2 domain-containing protein 5

 SH2 domain-containing protein 5 ELISA Kit
 SH2 domain-containing protein 5 Recombinant
 SH2 domain-containing protein 5 Antibody
SH2D5: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Unknown function

Cellular Component: postsynaptic density

Molecular Function: protein binding
 Sh2d5 ELISA Kit
 Sh2d5 Recombinant
 Sh2d5 Antibody
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SH2 domain-containing protein 6

 SH2 domain-containing protein 6 ELISA Kit
 SH2 domain-containing protein 6 Recombinant
 SH2 domain-containing protein 6 Antibody
SH2D6: 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: intracellular

Biological Process: immune response; transmembrane receptor protein tyrosine kinase signaling pathway
 Sh2d6 ELISA Kit
 Sh2d6 Recombinant
 Sh2d6 Antibody
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SH2 domain-containing protein 7

 SH2 domain-containing protein 7 ELISA Kit
 SH2 domain-containing protein 7 Recombinant
 SH2 domain-containing protein 7 Antibody
SH2D7:

Chromosomal Location of Human Ortholog: 15q25.1
 SH2D7 ELISA Kit
 SH2D7 Recombinant
 SH2D7 Antibody
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Proteins Root Name Listing
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