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SH2B adapter protein

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).

Below are the list of possible SH2B adapter protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

SH2B adapter protein 1

 SH2B adapter protein 1 ELISA Kit
 SH2B adapter protein 1 Recombinant
 SH2B adapter protein 1 Antibody
Also known as SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1).
SH2-B-beta: an adaptor protein that specifically activates JAK2 and serve as adapter proteins for JAK1, -2 and -3. YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.

Protein type: Adaptor/scaffold

Molecular Function: protein binding

Biological Process: lamellipodium biogenesis; positive regulation of mitosis
 Sh2b1 ELISA Kit
 Sh2b1 Recombinant
 Sh2b1 Antibody
 Sh2-b ELISA Kit
 Sh2-b Recombinant
 Sh2-b Antibody
 Sh2bpsm1 ELISA Kit
 Sh2bpsm1 Recombinant
 Sh2bpsm1 Antibody
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SH2B adapter protein 2

 SH2B adapter protein 2 ELISA Kit
 SH2B adapter protein 2 Recombinant
 SH2B adapter protein 2 Antibody
Also known as SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS).
APS: an adapter protein involved in coupling immunoreceptors to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a mas
king effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. Interacts with several proteins including KIT/c-KIT, SHC, GRB2, EPOR, CBL/c-CBL, PDGFR, VAV1 and VAV3. Interacts with SHC through its N-terminal region, with GRB2 via the phosphorylated C-terminus and with EPOR and KIT via its SH2 domain. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts with VAV3 via its PH domain, inducing cytoskeletal reorganization. Expressed in spleen, prostrate, testis, uterus, small intestine and skeletal muscle. Among haematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.

Protein type: Adaptor/scaffold

Cellular Component: actin filament; cytoplasm; plasma membrane; ruffle; stress fiber

Molecular Function: identical protein binding; JAK pathway signal transduction adaptor activity; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: actin cytoskeleton organization and biogenesis; antigen receptor-mediated signaling pathway; B-1 B cell homeostasis; brown fat cell differentiation; cytokine and chemokine mediated signaling pathway; insulin receptor signaling pathway; nervous system development; regulation of immune response; regulation of metabolic process; regulation of Ras protein signal transduction
 Sh2b2 ELISA Kit
 Sh2b2 Recombinant
 Sh2b2 Antibody
 Aps ELISA Kit
 Aps Recombinant
 Aps Antibody
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SH2B adapter protein 3

 SH2B adapter protein 3 ELISA Kit
 SH2B adapter protein 3 Recombinant
 SH2B adapter protein 3 Antibody
Also known as SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk).
transmits activated T-cell receptor signal to phosphatidylinositol 3-kinase, phospholipase C gamma 1 and Ras signaling pathways [RGD, Feb 2006]
 Sh2b3 ELISA Kit
 Sh2b3 Recombinant
 Sh2b3 Antibody
 Lnk ELISA Kit
 Lnk Recombinant
 Lnk Antibody
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