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SH3 and PX domain-containing protein

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Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation.

Below are the list of possible SH3 and PX domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

SH3 and PX domain-containing protein 2A

 SH3 and PX domain-containing protein 2A ELISA Kit
 SH3 and PX domain-containing protein 2A Recombinant
 SH3 and PX domain-containing protein 2A Antibody
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation.
 sh3pxd2a ELISA Kit
 sh3pxd2a Recombinant
 sh3pxd2a Antibody
 si:dkey-82d4.2 ELISA Kit
 si:dkey-82d4.2 Recombinant
 si:dkey-82d4.2 Antibody
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SH3 and PX domain-containing protein 2B

 SH3 and PX domain-containing protein 2B ELISA Kit
 SH3 and PX domain-containing protein 2B Recombinant
 SH3 and PX domain-containing protein 2B Antibody
Also known as SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains).
SH3PXD2B: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation
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. Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS). It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers. Belongs to the SH3PXD2 family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoplasm; podosome

Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; SH2 domain binding; superoxide-generating NADPH oxidase activator activity

Biological Process: extracellular matrix disassembly; eye development; heart development; skeletal development; superoxide metabolic process

Disease: Frank-ter Haar Syndrome
 SH3PXD2B ELISA Kit
 SH3PXD2B Recombinant
 SH3PXD2B Antibody
 FAD49 ELISA Kit
 FAD49 Recombinant
 FAD49 Antibody
 KIAA1295 ELISA Kit
 KIAA1295 Recombinant
 KIAA1295 Antibody
 TKS4 ELISA Kit
 TKS4 Recombinant
 TKS4 Antibody
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