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SHC-transforming protein

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Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Below are the list of possible SHC-transforming protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

SHC-transforming protein 1

 SHC-transforming protein 1 ELISA Kit
 SHC-transforming protein 1 Recombinant
 SHC-transforming protein 1 Antibody
Also known as SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1).
SHC1: an adaptor protein containing a SH2 domain and a PID domain within a PH domain-like fold. Couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Six human isoforms are produced by alternative promoter usage and alternative splicing. Isoforms p66, p52 and p46 (P29353-1, -2, and -3), produced by alternative initiation, v
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ariously regulate growth factor signaling, oncogenesis, intracellular oxidant levels, and apoptosis. Isoforms p46 and p52, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex, thus initiating the cytoplasmic proliferative Ras signaling cascade in various non-neuronal systems. Isoform p66 does not mediate Ras activation, but associates with mitochondria where it controls intracellular redox status, mitochondrial permeability, life span, and stress-induced apoptosis. p66 acts as a downstream target of the tumor suppressor p53 and is required for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. P66 deletion in mice decreases the incidence of aging-associated diseases, such as atherosclerosis, and significantly prolongs life span. Participates in signaling downstream of TIE2, the tyrosine kinase receptor for angiopoietin, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Interacts with tyrosine-phosphorylated CD3T, DDR2, LRP1, IRS4, SHP, FLT4, PDGFRB, TIE2, TrkA, -B and -C. Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. p66Shc is known to be activated by the mutant SOD1 associated with familial forms of amyotrophic lateral sclerosis (ALS), causing a decrease in the activity of Rac1 through a redox-sensitive regulation. In case of oxidative conditions, phosphorylation at S36 of isoform p66Shc, leads to mitochondrial accumulation p66 plays a role in mediating mitophagy and determining neuronal cell fate following acute oxygen glucose deprivation. Isoform p46 is localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.

Protein type: Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytosol; plasma membrane

Molecular Function: ephrin receptor binding; epidermal growth factor receptor binding; insulin receptor binding; insulin-like growth factor receptor binding; neurotrophin TRKA receptor binding; phospholipid binding; protein binding; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: activation of MAPK activity; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; positive regulation of DNA replication; Ras protein signal transduction; regulation of epidermal growth factor receptor activity
 SHC1 ELISA Kit
 SHC1 Recombinant
 SHC1 Antibody
 SHC ELISA Kit
 SHC Recombinant
 SHC Antibody
 SHCA ELISA Kit
 SHCA Recombinant
 SHCA Antibody
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SHC-transforming protein 2

 SHC-transforming protein 2 ELISA Kit
 SHC-transforming protein 2 Recombinant
 SHC-transforming protein 2 Antibody
Also known as SHC-transforming protein 2 (Protein Sck) (Protein Sli) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2).
SHC2: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors
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in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Cellular Component: plasma membrane

Molecular Function: receptor tyrosine kinase binding

Biological Process: transmembrane receptor protein tyrosine kinase signaling pathway
 Shc2 ELISA Kit
 Shc2 Recombinant
 Shc2 Antibody
 Sck ELISA Kit
 Sck Recombinant
 Sck Antibody
 ShcB ELISA Kit
 ShcB Recombinant
 ShcB Antibody
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SHC-transforming protein 3

 SHC-transforming protein 3 ELISA Kit
 SHC-transforming protein 3 Recombinant
 SHC-transforming protein 3 Antibody
Also known as SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3).
SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk
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receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: cytosol; plasma membrane

Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; signal transducer activity

Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
 SHC3 ELISA Kit
 SHC3 Recombinant
 SHC3 Antibody
 NSHC ELISA Kit
 NSHC Recombinant
 NSHC Antibody
 SHCC ELISA Kit
 SHCC Recombinant
 SHCC Antibody
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SHC-transforming protein 4

 SHC-transforming protein 4 ELISA Kit
 SHC-transforming protein 4 Recombinant
 SHC-transforming protein 4 Antibody
Also known as SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4).
SHC4: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q21.1-q21.2

Cellular Component: plasma membrane

Molecular Functio
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n: protein binding; receptor tyrosine kinase binding

Biological Process: transmembrane receptor protein tyrosine kinase signaling pathway
 SHC4 ELISA Kit
 SHC4 Recombinant
 SHC4 Antibody
 SHCD ELISA Kit
 SHCD Recombinant
 SHCD Antibody
 UNQ6438/PRO21364 ELISA Kit
 UNQ6438/PRO21364 Recombinant
 UNQ6438/PRO21364 Antibody
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SHC-transforming protein homolog 1

 SHC-transforming protein homolog 1 ELISA Kit
 SHC-transforming protein homolog 1 Recombinant
 SHC-transforming protein homolog 1 Antibody
Also known as SHC-transforming protein homolog 1 (Src homology 2 domain adapter homolog 1).
Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1 (PubMed:18832074, PubMed:18809575). In addition,
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negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway (PubMed:18832074). Involved in the response to several environmental stresses including heavy metal ions (Cu2+ and Cd2+), heat, oxidative and protein misfolding (ER) stresses (PubMed:18832074, PubMed:18809575). Plays a role in life span, egg laying and in axon regeneration after injury (PubMed:18832074, PubMed:23072806).
 shc-1 ELISA Kit
 shc-1 Recombinant
 shc-1 Antibody
 F54A5.3 ELISA Kit
 F54A5.3 Recombinant
 F54A5.3 Antibody
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Proteins Root Name Listing
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