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Shugoshin

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Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.

Below are the list of possible Shugoshin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Shugoshin

 Shugoshin ELISA Kit
 Shugoshin Recombinant
 Shugoshin Antibody
Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
 sgo-1 ELISA Kit
 sgo-1 Recombinant
 sgo-1 Antibody
 C33H5.15 ELISA Kit
 C33H5.15 Recombinant
 C33H5.15 Antibody
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Shugoshin 1

 Shugoshin 1 ELISA Kit
 Shugoshin 1 Recombinant
 Shugoshin 1 Antibody
Also known as Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1).
SGO1: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex
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at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Belongs to the shugoshin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 3p24.3

Cellular Component: centrosome; chromosome, pericentric region; cytoplasm; cytosol; kinetochore; nucleoplasm; spindle pole

Molecular Function: kinase binding; protein binding

Biological Process: attachment of spindle microtubules to kinetochore; centriole-centriole cohesion; chromosome segregation; meiotic chromosome segregation; sister chromatid cohesion

Disease: Chronic Atrial And Intestinal Dysrhythmia
 SGO1 ELISA Kit
 SGO1 Recombinant
 SGO1 Antibody
 SGOL1 ELISA Kit
 SGOL1 Recombinant
 SGOL1 Antibody
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Shugoshin 2

 Shugoshin 2 ELISA Kit
 Shugoshin 2 Recombinant
 Shugoshin 2 Antibody
Also known as Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2).
SGOL2: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin depho
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sphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Belongs to the shugoshin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; kinetochore; nucleoplasm

Biological Process: female meiosis; male meiosis; meiotic sister chromatid cohesion, centromeric; protein localization
 Sgo2 ELISA Kit
 Sgo2 Recombinant
 Sgo2 Antibody
 Sgol2 ELISA Kit
 Sgol2 Recombinant
 Sgol2 Antibody
 Sgol2a ELISA Kit
 Sgol2a Recombinant
 Sgol2a Antibody
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Shugoshin-1

 Shugoshin-1 ELISA Kit
 Shugoshin-1 Recombinant
 Shugoshin-1 Antibody
Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I.
 sgo1 ELISA Kit
 sgo1 Recombinant
 sgo1 Antibody
 SPBP35G2.03c ELISA Kit
 SPBP35G2.03c Recombinant
 SPBP35G2.03c Antibody
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Shugoshin-2

 Shugoshin-2 ELISA Kit
 Shugoshin-2 Recombinant
 Shugoshin-2 Antibody
Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during m
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eiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis.
 sgo2 ELISA Kit
 sgo2 Recombinant
 sgo2 Antibody
 SPAC15A10.15 ELISA Kit
 SPAC15A10.15 Recombinant
 SPAC15A10.15 Antibody
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Proteins Root Name Listing
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