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Sigma non-opioid intracellular receptor

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Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration .

Below are the list of possible Sigma non-opioid intracellular receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sigma non-opioid intracellular receptor 1

 Sigma non-opioid intracellular receptor 1 ELISA Kit
 Sigma non-opioid intracellular receptor 1 Recombinant
 Sigma non-opioid intracellular receptor 1 Antibody
Also known as Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1).
SIGMAR1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate n
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eurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Defects in SIGMAR1 are the cause of amyotrophic lateral sclerosis type 16, juvenile (ALS16). ALS16 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Belongs to the ERG2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nuclear envelope; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: endoplasmic reticulum; integral to membrane; integral to plasma membrane; nuclear envelope; postsynaptic density

Molecular Function: drug binding

Biological Process: regulation of neuron apoptosis

Disease: Amyotrophic Lateral Sclerosis 16, Juvenile; Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2
 SIGMAR1 ELISA Kit
 SIGMAR1 Recombinant
 SIGMAR1 Antibody
 OPRS1 ELISA Kit
 OPRS1 Recombinant
 OPRS1 Antibody
 SRBP ELISA Kit
 SRBP Recombinant
 SRBP Antibody
 AAG8 ELISA Kit
 AAG8 Recombinant
 AAG8 Antibody
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