| Sigma non-opioid intracellular receptor 1 ELISA Kit|
Sigma non-opioid intracellular receptor 1 Recombinant
Sigma non-opioid intracellular receptor 1 Antibody
|Also known as Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1). |
SIGMAR1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate n
eurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Defects in SIGMAR1 are the cause of amyotrophic lateral sclerosis type 16, juvenile (ALS16). ALS16 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Belongs to the ERG2 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Nuclear envelope; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: endoplasmic reticulum; integral to membrane; integral to plasma membrane; nuclear envelope; postsynaptic density
Molecular Function: drug binding
Biological Process: regulation of neuron apoptosis
Disease: Amyotrophic Lateral Sclerosis 16, Juvenile; Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2
| SIGMAR1 ELISA Kit|
| OPRS1 ELISA Kit|
| SRBP ELISA Kit|
| AAG8 ELISA Kit|