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Signal transducer and activator of transcription

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Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Below are the list of possible Signal transducer and activator of transcription products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Signal transducer and activator of transcription 1

 Signal transducer and activator of transcription 1 ELISA Kit
 Signal transducer and activator of transcription 1 Recombinant
 Signal transducer and activator of transcription 1 Antibody
STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-b
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inding; Transcription factor

Cellular Component: axon; cell-cell adherens junction; cytoplasm; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: CCR5 chemokine receptor binding; DNA binding; double-stranded DNA binding; enzyme binding; nuclear hormone receptor binding; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; transcription factor activity; tumor necrosis factor receptor binding

Biological Process: blood circulation; caspase activation; cellular response to insulin stimulus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral protein levels in host cell; positive regulation of cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to bacterium; response to cAMP; response to cytokine stimulus; response to drug; response to exogenous dsRNA; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to peptide hormone stimulus; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway
 Stat1 ELISA Kit
 Stat1 Recombinant
 Stat1 Antibody
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Signal transducer and activator of transcription 1-alpha/beta

 Signal transducer and activator of transcription 1-alpha/beta ELISA Kit
 Signal transducer and activator of transcription 1-alpha/beta Recombinant
 Signal transducer and activator of transcription 1-alpha/beta Antibody
Also known as Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84).
STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into
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the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: axon; cell-cell adherens junction; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: double-stranded DNA binding; enzyme binding; identical protein binding; nuclear hormone receptor binding; protein binding; protein homodimerization activity; transcription factor activity; tumor necrosis factor receptor binding

Biological Process: apoptosis; blood circulation; endothelial cell migration; JAK-STAT cascade; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to cAMP; response to cytokine stimulus; response to peptide hormone stimulus; tumor necrosis factor-mediated signaling pathway

Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
 STAT1 ELISA Kit
 STAT1 Recombinant
 STAT1 Antibody
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Signal transducer and activator of transcription 2

 Signal transducer and activator of transcription 2 ELISA Kit
 Signal transducer and activator of transcription 2 Recombinant
 Signal transducer and activator of transcription 2 Antibody
STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcriptio
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n factor

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: protein binding

Biological Process: defense response to virus; regulation of protein amino acid phosphorylation
 Stat2 ELISA Kit
 Stat2 Recombinant
 Stat2 Antibody
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Signal transducer and activator of transcription 3

 Signal transducer and activator of transcription 3 ELISA Kit
 Signal transducer and activator of transcription 3 Recombinant
 Signal transducer and activator of transcription 3 Antibody
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters o
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f various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (). May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity ().
 STAT3 ELISA Kit
 STAT3 Recombinant
 STAT3 Antibody
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Signal transducer and activator of transcription 3.1

 Signal transducer and activator of transcription 3.1 ELISA Kit
 Signal transducer and activator of transcription 3.1 Recombinant
 Signal transducer and activator of transcription 3.1 Antibody
Also known as Signal transducer and activator of transcription 3.1 (Protein Stat3) (Xstat3).
Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling. Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differe
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ntiation. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk.2.
 stat3.1 ELISA Kit
 stat3.1 Recombinant
 stat3.1 Antibody
 stat3 ELISA Kit
 stat3 Recombinant
 stat3 Antibody
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Signal transducer and activator of transcription 3.2

 Signal transducer and activator of transcription 3.2 ELISA Kit
 Signal transducer and activator of transcription 3.2 Recombinant
 Signal transducer and activator of transcription 3.2 Antibody
Also known as Signal transducer and activator of transcription 3.2 (Protein Stat3-A).
Transcription factor that binds to target promoter sequences and activates transcription upon il6st/gp130 stimulation. Mediates ventralization of embryos, at least in part via inhibition of smad2 signaling. Required for hairy2 to induce dll1/delta1 and promote neural crest cell proliferation and differentiatio
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n. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 and nlk.2 ().
 stat3.2 ELISA Kit
 stat3.2 Recombinant
 stat3.2 Antibody
 stat3-a ELISA Kit
 stat3-a Recombinant
 stat3-a Antibody
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Signal transducer and activator of transcription 4

 Signal transducer and activator of transcription 4 ELISA Kit
 Signal transducer and activator of transcription 4 Recombinant
 Signal transducer and activator of transcription 4 Antibody
STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; nucleus

Molecular Fu
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nction: DNA binding; protein binding; sequence-specific DNA binding

Biological Process: cell proliferation; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation
 Stat4 ELISA Kit
 Stat4 Recombinant
 Stat4 Antibody
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Signal transducer and activator of transcription 5A

 Signal transducer and activator of transcription 5A ELISA Kit
 Signal transducer and activator of transcription 5A Recombinant
 Signal transducer and activator of transcription 5A Antibody
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation ().
 STAT5A ELISA Kit
 STAT5A Recombinant
 STAT5A Antibody
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Signal transducer and activator of transcription 5B

 Signal transducer and activator of transcription 5B ELISA Kit
 Signal transducer and activator of transcription 5B Recombinant
 Signal transducer and activator of transcription 5B Antibody
STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers th
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at translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: chromatin binding; glucocorticoid receptor binding; protein binding; protein dimerization activity; protein-tyrosine kinase activity; transcription factor activity

Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; cellular response to hormone stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; isoleucine metabolic process; JAK-STAT cascade; oxaloacetate metabolic process; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; succinate metabolic process; taurine metabolic process; valine metabolic process

Disease: Growth Hormone Insensitivity With Immunodeficiency
 STAT5B ELISA Kit
 STAT5B Recombinant
 STAT5B Antibody
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Signal transducer and activator of transcription 6

 Signal transducer and activator of transcription 6 ELISA Kit
 Signal transducer and activator of transcription 6 Recombinant
 Signal transducer and activator of transcription 6 Antibody
Also known as Signal transducer and activator of transcription 6 (IL-4 Stat).
STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or
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heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: identical protein binding; protein binding; protein phosphatase binding

Biological Process: positive regulation of interferon type I production; regulation of transcription from RNA polymerase II promoter; signal transduction
 STAT6 ELISA Kit
 STAT6 Recombinant
 STAT6 Antibody
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Signal transducer and activator of transcription A

 Signal transducer and activator of transcription A ELISA Kit
 Signal transducer and activator of transcription A Recombinant
 Signal transducer and activator of transcription A Antibody
Also known as Signal transducer and activator of transcription A (Dd-STATa) (STAT5 homolog A).
Transcription factor that binds to 5'-TTGAATTGA-3' elements in the promoter region of target genes. Functions as repressor of the ecmB gene. Regulates the differentiation of prestalk cells during development.
 dstA ELISA Kit
 dstA Recombinant
 dstA Antibody
 stat5 ELISA Kit
 stat5 Recombinant
 stat5 Antibody
 statA ELISA Kit
 statA Recombinant
 statA Antibody
 DDB_G0281381 ELISA Kit
 DDB_G0281381 Recombinant
 DDB_G0281381 Antibody
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Signal transducer and activator of transcription B

 Signal transducer and activator of transcription B ELISA Kit
 Signal transducer and activator of transcription B Recombinant
 Signal transducer and activator of transcription B Antibody
Also known as Signal transducer and activator of transcription B (Dd-STATb) (STAT5 homolog B).
Transcription factor that regulates gene expression during development. Required for optimal cell growth.
 dstB ELISA Kit
 dstB Recombinant
 dstB Antibody
 statB ELISA Kit
 statB Recombinant
 statB Antibody
 DDB_G0268638 ELISA Kit
 DDB_G0268638 Recombinant
 DDB_G0268638 Antibody
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Signal transducer and activator of transcription C

 Signal transducer and activator of transcription C ELISA Kit
 Signal transducer and activator of transcription C Recombinant
 Signal transducer and activator of transcription C Antibody
Also known as Signal transducer and activator of transcription C (Dd-STATc) (STAT5 homolog C).
Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.
 dstC ELISA Kit
 dstC Recombinant
 dstC Antibody
 statC ELISA Kit
 statC Recombinant
 statC Antibody
 DDB_G0293532 ELISA Kit
 DDB_G0293532 Recombinant
 DDB_G0293532 Antibody
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