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Signal-transducing adaptor protein

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In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

Below are the list of possible Signal-transducing adaptor protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Signal-transducing adaptor protein 1

 Signal-transducing adaptor protein 1 ELISA Kit
 Signal-transducing adaptor protein 1 Recombinant
 Signal-transducing adaptor protein 1 Antibody
Also known as Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1).
STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induc
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es pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: cytoplasm; mitochondrion; nucleus; protein complex

Molecular Function: phosphotyrosine binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: negative regulation of phosphorylation; positive regulation of B cell receptor signaling pathway; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway
 STAP1 ELISA Kit
 STAP1 Recombinant
 STAP1 Antibody
 BRDG1 ELISA Kit
 BRDG1 Recombinant
 BRDG1 Antibody
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Signal-transducing adaptor protein 2

 Signal-transducing adaptor protein 2 ELISA Kit
 Signal-transducing adaptor protein 2 Recombinant
 Signal-transducing adaptor protein 2 Antibody
Also known as Signal-transducing adaptor protein 2 (STAP-2).
STAP2: a widely expressed proimflammatory adaptor protein that regulates immune and inflammatory responses. Binds and modulates a variety of molecules including Brk, CSFR, FCER1, and BCR-ABL. The interaction between STAP-2 and BCR-ABL appears to provide a growth advantage to BCR-ABL+ chronic myeloid leukemia cells. Suppression of STA
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P-2 expression in K562 CML cells suppressed tumor formation in mice. Enables intestinal proinflammatory responses in vivo: promotes macrophage recruitment in dextran sodium sulfate induced colitis, and promotes the ability of CXCL12-induced migration in macrophages. STAP-2 knockdown in T47D breast cancer cells induced a significant decrease of proliferation. Contains a pleckstrin homology, Src homology 2-like, and as well as a STAT3-binding domains. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: plasma membrane

Molecular Function: protein binding
 Stap2 ELISA Kit
 Stap2 Recombinant
 Stap2 Antibody
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