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Single Ig IL-1-related receptor

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Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).

Below are the list of possible Single Ig IL-1-related receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Single Ig IL-1-related receptor

 Single Ig IL-1-related receptor ELISA Kit
 Single Ig IL-1-related receptor Recombinant
 Single Ig IL-1-related receptor Antibody
Also known as Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).
SIGIRR: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR d
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omain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane

Biological Process: acute-phase response; negative regulation of chemokine biosynthetic process; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of transcription factor activity
 Sigirr ELISA Kit
 Sigirr Recombinant
 Sigirr Antibody
 Tir8 ELISA Kit
 Tir8 Recombinant
 Tir8 Antibody
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