| Single Ig IL-1-related receptor ELISA Kit|
Single Ig IL-1-related receptor Recombinant
Single Ig IL-1-related receptor Antibody
|Also known as Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8). |
SIGIRR: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR d
omain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: membrane
Biological Process: acute-phase response; negative regulation of chemokine biosynthetic process; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of transcription factor activity
| Sigirr ELISA Kit|
| Tir8 ELISA Kit|