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SLIT-ROBO Rho GTPase-activating protein

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GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Below are the list of possible SLIT-ROBO Rho GTPase-activating protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

SLIT-ROBO Rho GTPase-activating protein 1

 SLIT-ROBO Rho GTPase-activating protein 1 ELISA Kit
 SLIT-ROBO Rho GTPase-activating protein 1 Recombinant
 SLIT-ROBO Rho GTPase-activating protein 1 Antibody
Also known as SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13).
ARHGAP13: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 12q14.2
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Cellular Component: cytoplasm; cytosol

Molecular Function: GTPase activator activity; protein binding; Rac GTPase binding

Biological Process: negative regulation of cell migration; regulation of small GTPase mediated signal transduction

Disease: Thyroid Carcinoma, Follicular
 SRGAP1 ELISA Kit
 SRGAP1 Recombinant
 SRGAP1 Antibody
 ARHGAP13 ELISA Kit
 ARHGAP13 Recombinant
 ARHGAP13 Antibody
 KIAA1304 ELISA Kit
 KIAA1304 Recombinant
 KIAA1304 Antibody
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SLIT-ROBO Rho GTPase-activating protein 2

 SLIT-ROBO Rho GTPase-activating protein 2 ELISA Kit
 SLIT-ROBO Rho GTPase-activating protein 2 Recombinant
 SLIT-ROBO Rho GTPase-activating protein 2 Antibody
Also known as SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2).
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. May play a role in different aspects of neuronal morphogenesis and migration. This includes the biogenesis of neurites, where it could be required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. May also stimulate the branching of the leading process and negatively regulates neuron migration. In non-neuronal cells, it may also play a role in cel
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l migration by regulating the formation of lamellipodia and filopodia ().
 srgap2 ELISA Kit
 srgap2 Recombinant
 srgap2 Antibody
 srgap2a ELISA Kit
 srgap2a Recombinant
 srgap2a Antibody
 si:dkey-85p17.1 ELISA Kit
 si:dkey-85p17.1 Recombinant
 si:dkey-85p17.1 Antibody
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SLIT-ROBO Rho GTPase-activating protein 2B

 SLIT-ROBO Rho GTPase-activating protein 2B ELISA Kit
 SLIT-ROBO Rho GTPase-activating protein 2B Recombinant
 SLIT-ROBO Rho GTPase-activating protein 2B Antibody
Also known as SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2).
SRGAP2B: May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. {ECO:0000305|PubMed:22559944}. Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function. {ECO:0000250}

Chromosomal Location of Human Ortho
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log: 1q21.1
 SRGAP2B ELISA Kit
 SRGAP2B Recombinant
 SRGAP2B Antibody
 SRGAP2P2 ELISA Kit
 SRGAP2P2 Recombinant
 SRGAP2P2 Antibody
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SLIT-ROBO Rho GTPase-activating protein 2C

 SLIT-ROBO Rho GTPase-activating protein 2C ELISA Kit
 SLIT-ROBO Rho GTPase-activating protein 2C Recombinant
 SLIT-ROBO Rho GTPase-activating protein 2C Antibody
Also known as SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1).
SRGAP2C: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and
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memory. Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 function

Chromosomal Location of Human Ortholog: 1p11.2

Cellular Component: cytoplasm

Molecular Function: GTPase activator activity; protein heterodimerization activity; protein homodimerization activity; Rac GTPase binding

Biological Process: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; negative regulation of cell migration; negative regulation of filopodium formation
 SRGAP2C ELISA Kit
 SRGAP2C Recombinant
 SRGAP2C Antibody
 SRGAP2P1 ELISA Kit
 SRGAP2P1 Recombinant
 SRGAP2P1 Antibody
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SLIT-ROBO Rho GTPase-activating protein 3

 SLIT-ROBO Rho GTPase-activating protein 3 ELISA Kit
 SLIT-ROBO Rho GTPase-activating protein 3 Recombinant
 SLIT-ROBO Rho GTPase-activating protein 3 Antibody
Also known as SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP).
ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho

Chromosomal Loc
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ation of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; cytosol

Molecular Function: GTPase activator activity; protein binding; Rac GTPase binding

Biological Process: negative regulation of cell migration; regulation of small GTPase mediated signal transduction
 SRGAP3 ELISA Kit
 SRGAP3 Recombinant
 SRGAP3 Antibody
 ARHGAP14 ELISA Kit
 ARHGAP14 Recombinant
 ARHGAP14 Antibody
 KIAA0411 ELISA Kit
 KIAA0411 Recombinant
 KIAA0411 Antibody
 KIAA1156 ELISA Kit
 KIAA1156 Recombinant
 KIAA1156 Antibody
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