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Snaclec echicetin

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Echicetin itself inhibits aggregation of washed platelets induced by vWF, thrombin or alboaggregin-A .

Below are the list of possible Snaclec echicetin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Snaclec echicetin subunit alpha

 Snaclec echicetin subunit alpha ELISA Kit
 Snaclec echicetin subunit alpha Recombinant
 Snaclec echicetin subunit alpha Antibody
Echicetin itself inhibits aggregation of washed platelets induced by vWF, thrombin or alboaggregin-A (PubMed:8481512, PubMed:11290595). However, when complexed with the pentameric plasma immunoglobuli
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n Mkappa (IgMkappa), echicetin binds specifically to GPIb and activates platelets. This is caused by P-selectin expression and activation of alpha-IIb/beta-3 as well as tyrosine phosphorylation of several signal transduction molecules, including p53/56(LYN), p64, p72(SYK), p70 to p90, and p120 (PubMed:11290595). In vivo, it induces thrombocytopenia when injected into mice (PubMed:8481512), probably accounting of activation of platelets rather than inhibition (PubMed:11290595).
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Snaclec echicetin subunit beta

 Snaclec echicetin subunit beta ELISA Kit
 Snaclec echicetin subunit beta Recombinant
 Snaclec echicetin subunit beta Antibody
Binding of echicetin to glycoprotein Ibalpha (GP1BA) receptor on platelets alone results in inhibition of platelet aggregation, while binding to both GPIba receptor and IgMk promotes platelet aggregat
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ion and signal transduction.
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