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SNW domain-containing protein

Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Below are the list of possible SNW domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

SNW domain-containing protein 1

 SNW domain-containing protein 1 ELISA Kit
 SNW domain-containing protein 1 Recombinant
 SNW domain-containing protein 1 Antibody
Also known as SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein).
Skip: Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing. Belongs to the SNW family.

Protein type: Nuclear receptor co-regulator; Spliceosome; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nuclear matrix; nucleoplasm; nucleus; spliceosome; transcription elongation factor complex b

Molecular Function: Notch binding; nuclea
r hormone receptor binding; protein binding; retinoic acid receptor binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; vitamin D receptor binding

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; nuclear mRNA splicing, via spliceosome; positive regulation of histone H3-K4 methylation; positive regulation of neurogenesis; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of retinoic acid receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter
 SNW1 Recombinant
 SNW1 Antibody
 SKIIP Recombinant
 SKIIP Antibody
 SKIP Recombinant
 SKIP Antibody
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