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Sodium-coupled monocarboxylate transporter

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Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Below are the list of possible Sodium-coupled monocarboxylate transporter products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sodium-coupled monocarboxylate transporter 1

 Sodium-coupled monocarboxylate transporter 1 ELISA Kit
 Sodium-coupled monocarboxylate transporter 1 Recombinant
 Sodium-coupled monocarboxylate transporter 1 Antibody
Also known as Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8).
SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxyb
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utyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Tumor suppressor

Chromosomal Location of Human Ortholog: 12q23.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: monocarboxylic acid transmembrane transporter activity; passive transmembrane transporter activity; symporter activity

Biological Process: ion transport
 SLC5A8 ELISA Kit
 SLC5A8 Recombinant
 SLC5A8 Antibody
 AIT ELISA Kit
 AIT Recombinant
 AIT Antibody
 SMCT ELISA Kit
 SMCT Recombinant
 SMCT Antibody
 SMCT1 ELISA Kit
 SMCT1 Recombinant
 SMCT1 Antibody
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Sodium-coupled monocarboxylate transporter 2

 Sodium-coupled monocarboxylate transporter 2 ELISA Kit
 Sodium-coupled monocarboxylate transporter 2 Recombinant
 Sodium-coupled monocarboxylate transporter 2 Antibody
Also known as Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12).
SLC5A12: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate
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, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane

Molecular Function: lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; symporter activity
 Slc5a12 ELISA Kit
 Slc5a12 Recombinant
 Slc5a12 Antibody
 Smct2 ELISA Kit
 Smct2 Recombinant
 Smct2 Antibody
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