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Sortilin-related receptor

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Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Below are the list of possible Sortilin-related receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sortilin-related receptor

 Sortilin-related receptor ELISA Kit
 Sortilin-related receptor Recombinant
 Sortilin-related receptor Antibody
Also known as Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA).
SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Bind
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s LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Cellular Component: cell soma; early endosome; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; Golgi cisterna; membrane; multivesicular body; nuclear envelope lumen; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network

Molecular Function: ADP-ribosylation factor binding; beta-amyloid binding; low-density lipoprotein binding; protein binding

Biological Process: cell migration; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi; protein targeting; protein targeting to Golgi; protein targeting to lysosome; regulation of smooth muscle cell migration
 Sorl1 ELISA Kit
 Sorl1 Recombinant
 Sorl1 Antibody
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