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Sorting nexin

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Plays a role in vesicular protein sorting. Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport via its interaction with the BLOS1/2 proteins and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport. Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the trafficking of several plasma membrane proteins. Also involved in the efficient sorting of seed storage protein globulin 12S.

Below are the list of possible Sorting nexin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sorting nexin 1

 Sorting nexin 1 ELISA Kit
 Sorting nexin 1 Recombinant
 Sorting nexin 1 Antibody
Also known as Sorting nexin 1 (AtSNX1) (Vacuolar protein sorting-associated protein 5 homolog).
Homolog of yeast retromer subunit VPS5. Part of a retromer-like protein complex involved in endosome to lysosome protein transport. In roots it co-localizes with the PIN2 auxin efflux carrier. Involved in endocytic sorting of membrane proteins including PIN2, BOR1 and BRI1.
 SNX1 ELISA Kit
 SNX1 Recombinant
 SNX1 Antibody
 VPS5 ELISA Kit
 VPS5 Recombinant
 VPS5 Antibody
 At5g06140 ELISA Kit
 At5g06140 Recombinant
 At5g06140 Antibody
 K16F4.11 ELISA Kit
 K16F4.11 Recombinant
 K16F4.11 Antibody
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Sorting nexin 2A

 Sorting nexin 2A ELISA Kit
 Sorting nexin 2A Recombinant
 Sorting nexin 2A Antibody
Plays a role in vesicular protein sorting (). Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport (). Also involved in the efficient sorting of seed storage protein globulin 12S.
 SNX2A ELISA Kit
 SNX2A Recombinant
 SNX2A Antibody
 At5g58440 ELISA Kit
 At5g58440 Recombinant
 At5g58440 Antibody
 MQJ2.4 ELISA Kit
 MQJ2.4 Recombinant
 MQJ2.4 Antibody
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Sorting nexin 2B

 Sorting nexin 2B ELISA Kit
 Sorting nexin 2B Recombinant
 Sorting nexin 2B Antibody
Encodes sorting nexin SNX2b. SNX2b is peripherally associated with membranes. Involved in vesicular trafficking from endosomes to the vacuole.
 SNX2B ELISA Kit
 SNX2B Recombinant
 SNX2B Antibody
 At5g07120 ELISA Kit
 At5g07120 Recombinant
 At5g07120 Antibody
 T28J14_60 ELISA Kit
 T28J14_60 Recombinant
 T28J14_60 Antibody
Table BarTOPTable Bar
 

Sorting nexin C1711.11

 Sorting nexin C1711.11 ELISA Kit
 Sorting nexin C1711.11 Recombinant
 Sorting nexin C1711.11 Antibody
 SPBC1711.11 ELISA Kit
 SPBC1711.11 Recombinant
 SPBC1711.11 Antibody
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Sorting nexin lst-4

 Sorting nexin lst-4 ELISA Kit
 Sorting nexin lst-4 Recombinant
 Sorting nexin lst-4 Antibody
Also known as Sorting nexin lst-4 (Lateral signaling target protein 4).
Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an intereaction with dyn-1. These are
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events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate.
 lst-4 ELISA Kit
 lst-4 Recombinant
 lst-4 Antibody
 Y37A1B.2 ELISA Kit
 Y37A1B.2 Recombinant
 Y37A1B.2 Antibody
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Sorting nexin MVP1

 Sorting nexin MVP1 ELISA Kit
 Sorting nexin MVP1 Recombinant
 Sorting nexin MVP1 Antibody
Required for vacuolar protein sorting.
 MVP1 ELISA Kit
 MVP1 Recombinant
 MVP1 Antibody
 CaJ7.0093 ELISA Kit
 CaJ7.0093 Recombinant
 CaJ7.0093 Antibody
 CaO19.7038 ELISA Kit
 CaO19.7038 Recombinant
 CaO19.7038 Antibody
 CaO19.7039 ELISA Kit
 CaO19.7039 Recombinant
 CaO19.7039 Antibody
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Sorting nexin-1

 Sorting nexin-1 ELISA Kit
 Sorting nexin-1 Recombinant
 Sorting nexin-1 Antibody
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes.
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This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
 SNX1 ELISA Kit
 SNX1 Recombinant
 SNX1 Antibody
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Sorting nexin-10

 Sorting nexin-10 ELISA Kit
 Sorting nexin-10 Recombinant
 Sorting nexin-10 Antibody
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption ().
 SNX10 ELISA Kit
 SNX10 Recombinant
 SNX10 Antibody
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Sorting nexin-10A

 Sorting nexin-10A ELISA Kit
 Sorting nexin-10A Recombinant
 Sorting nexin-10A Antibody
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.
 snx10a ELISA Kit
 snx10a Recombinant
 snx10a Antibody
 im:7153949 ELISA Kit
 im:7153949 Recombinant
 im:7153949 Antibody
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Sorting nexin-10B

 Sorting nexin-10B ELISA Kit
 Sorting nexin-10B Recombinant
 Sorting nexin-10B Antibody
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.
 snx10b ELISA Kit
 snx10b Recombinant
 snx10b Antibody
Table BarTOPTable Bar
 

Sorting nexin-11

 Sorting nexin-11 ELISA Kit
 Sorting nexin-11 Recombinant
 Sorting nexin-11 Antibody
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.
 SNX11 ELISA Kit
 SNX11 Recombinant
 SNX11 Antibody
Table BarTOPTable Bar
 

Sorting nexin-12

 Sorting nexin-12 ELISA Kit
 Sorting nexin-12 Recombinant
 Sorting nexin-12 Antibody
 snx12 ELISA Kit
 snx12 Recombinant
 snx12 Antibody
 SPCC16A11.04 ELISA Kit
 SPCC16A11.04 Recombinant
 SPCC16A11.04 Antibody
Table BarTOPTable Bar
 

Sorting nexin-13

 Sorting nexin-13 ELISA Kit
 Sorting nexin-13 Recombinant
 Sorting nexin-13 Antibody
SNX13: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Acts as a GAP for Galphas. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: early endosome

Molecular Function: phosphatidylinositol 3-phosphate binding; phosphoinositide binding

Biological
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Process: intracellular protein transport; positive regulation of GTPase activity
 Snx13 ELISA Kit
 Snx13 Recombinant
 Snx13 Antibody
Table BarTOPTable Bar
 

Sorting nexin-14

 Sorting nexin-14 ELISA Kit
 Sorting nexin-14 Recombinant
 Sorting nexin-14 Antibody
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (PubMed:25848753). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosph
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atidylinositol 3-phosphate (PtdIns(3P)) ().
 snx14 ELISA Kit
 snx14 Recombinant
 snx14 Antibody
Table BarTOPTable Bar
 

Sorting nexin-15

 Sorting nexin-15 ELISA Kit
 Sorting nexin-15 Recombinant
 Sorting nexin-15 Antibody
SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity)

Cellular Component: cytoplasm; nucleolus
 Snx15 ELISA Kit
 Snx15 Recombinant
 Snx15 Antibody
Table BarTOPTable Bar
 

Sorting nexin-16

 Sorting nexin-16 ELISA Kit
 Sorting nexin-16 Recombinant
 Sorting nexin-16 Antibody
SNX16: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Belongs to the sorting nexin family. 2 isofo
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rms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: early endosome; late endosome

Molecular Function: identical protein binding; phosphoinositide binding

Biological Process: early endosome to late endosome transport; endosome to lysosome transport; protein targeting to lysosome
 SNX16 ELISA Kit
 SNX16 Recombinant
 SNX16 Antibody
Table BarTOPTable Bar
 

Sorting nexin-17

 Sorting nexin-17 ELISA Kit
 Sorting nexin-17 Recombinant
 Sorting nexin-17 Antibody
SNX17: May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). Belongs to the sorting nexin family.

Protein type: Vesicle

Cel
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lular Component: cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bound organelle; protein complex

Molecular Function: low-density lipoprotein receptor binding; phosphoinositide binding; protein binding; protein C-terminus binding

Biological Process: intracellular protein transport; receptor-mediated endocytosis
 Snx17 ELISA Kit
 Snx17 Recombinant
 Snx17 Antibody
Table BarTOPTable Bar
 

Sorting nexin-17 homolog

 Sorting nexin-17 homolog ELISA Kit
 Sorting nexin-17 homolog Recombinant
 Sorting nexin-17 homolog Antibody
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
 snx-17 ELISA Kit
 snx-17 Recombinant
 snx-17 Antibody
 F17H10.3 ELISA Kit
 F17H10.3 Recombinant
 F17H10.3 Antibody
Table BarTOPTable Bar
 

Sorting nexin-18

 Sorting nexin-18 ELISA Kit
 Sorting nexin-18 Recombinant
 Sorting nexin-18 Antibody
Also known as Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1).
SNX18: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Belongs to the sorting nexin family. 2 isoforms of the huma
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n protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: clathrin-coated vesicle; cytoplasmic vesicle; endosome; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: cytokinesis after mitosis; endocytosis; endosome transport; positive regulation of GTPase activity; vesicle organization and biogenesis
 SNX18 ELISA Kit
 SNX18 Recombinant
 SNX18 Antibody
 SH3PXD3B ELISA Kit
 SH3PXD3B Recombinant
 SH3PXD3B Antibody
 SNAG1 ELISA Kit
 SNAG1 Recombinant
 SNAG1 Antibody
Table BarTOPTable Bar
 

Sorting nexin-19

 Sorting nexin-19 ELISA Kit
 Sorting nexin-19 Recombinant
 Sorting nexin-19 Antibody
SNX19: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: chondrocyte differentiation; insulin secretion
 SNX19 ELISA Kit
 SNX19 Recombinant
 SNX19 Antibody
 KIAA0254 ELISA Kit
 KIAA0254 Recombinant
 KIAA0254 Antibody
Table BarTOPTable Bar
 

Sorting nexin-2

 Sorting nexin-2 ELISA Kit
 Sorting nexin-2 Recombinant
 Sorting nexin-2 Antibody
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and i
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s involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN ().
 SNX2 ELISA Kit
 SNX2 Recombinant
 SNX2 Antibody
Table BarTOPTable Bar
 

Sorting nexin-20

 Sorting nexin-20 ELISA Kit
 Sorting nexin-20 Recombinant
 Sorting nexin-20 Antibody
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
 SNX20 ELISA Kit
 SNX20 Recombinant
 SNX20 Antibody
Table BarTOPTable Bar
 

Sorting nexin-21

 Sorting nexin-21 ELISA Kit
 Sorting nexin-21 Recombinant
 Sorting nexin-21 Antibody
SNX21: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.

Protein type: Vesicle

Cellular Component: early endosome membrane

Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding
 Snx21 ELISA Kit
 Snx21 Recombinant
 Snx21 Antibody
Table BarTOPTable Bar
 

Sorting nexin-22

 Sorting nexin-22 ELISA Kit
 Sorting nexin-22 Recombinant
 Sorting nexin-22 Antibody
SNX22: May be involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q22.31
 SNX22 ELISA Kit
 SNX22 Recombinant
 SNX22 Antibody
Table BarTOPTable Bar
 

Sorting nexin-24

 Sorting nexin-24 ELISA Kit
 Sorting nexin-24 Recombinant
 Sorting nexin-24 Antibody
May be involved in several stages of intracellular trafficking.
 SNX24 ELISA Kit
 SNX24 Recombinant
 SNX24 Antibody
Table BarTOPTable Bar
 

Sorting nexin-25

 Sorting nexin-25 ELISA Kit
 Sorting nexin-25 Recombinant
 Sorting nexin-25 Antibody
SNX25: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 4q35.1

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; receptor catabolic process
 SNX25 ELISA Kit
 SNX25 Recombinant
 SNX25 Antibody
 MSTP043 ELISA Kit
 MSTP043 Recombinant
 MSTP043 Antibody
Table BarTOPTable Bar
 

Sorting nexin-27

 Sorting nexin-27 ELISA Kit
 Sorting nexin-27 Recombinant
 Sorting nexin-27 Antibody
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmem
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brane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes ().
 SNX27 ELISA Kit
 SNX27 Recombinant
 SNX27 Antibody
Table BarTOPTable Bar
 

Sorting nexin-29

 Sorting nexin-29 ELISA Kit
 Sorting nexin-29 Recombinant
 Sorting nexin-29 Antibody
 SNX29 ELISA Kit
 SNX29 Recombinant
 SNX29 Antibody
Table BarTOPTable Bar
 

Sorting nexin-3

 Sorting nexin-3 ELISA Kit
 Sorting nexin-3 Recombinant
 Sorting nexin-3 Antibody
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) ().
 snx3 ELISA Kit
 snx3 Recombinant
 snx3 Antibody
 AO090020000309 ELISA Kit
 AO090020000309 Recombinant
 AO090020000309 Antibody
Table BarTOPTable Bar
 

Sorting nexin-30

 Sorting nexin-30 ELISA Kit
 Sorting nexin-30 Recombinant
 Sorting nexin-30 Antibody
SNX30: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.

Cellular Component: endosome; extrinsic to membrane

Molecular Function: phosphoinositide binding

Biological Process: endocytosis; vesicle organization and biogenesis
 Snx30 ELISA Kit
 Snx30 Recombinant
 Snx30 Antibody
Table BarTOPTable Bar
 

Sorting nexin-31

 Sorting nexin-31 ELISA Kit
 Sorting nexin-31 Recombinant
 Sorting nexin-31 Antibody
SNX31: May be involved in protein trafficking. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 8q22.3

Cellular Component: early endosome

Molecular Function: phosphoinositide binding; protein binding

Biological Process: intracellular protein transport
 SNX31 ELISA Kit
 SNX31 Recombinant
 SNX31 Antibody
Table BarTOPTable Bar
 

Sorting nexin-32

 Sorting nexin-32 ELISA Kit
 Sorting nexin-32 Recombinant
 Sorting nexin-32 Antibody
Also known as Sorting nexin-32 (Sorting nexin-6B).
SNX32: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: endosome; extrinsic to membrane

Molecular Function: phosphoinositide binding

Biological Process: endocytosis; vesicle organizat
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ion and biogenesis
 Snx32 ELISA Kit
 Snx32 Recombinant
 Snx32 Antibody
 Snx6b ELISA Kit
 Snx6b Recombinant
 Snx6b Antibody
Table BarTOPTable Bar
 

Sorting nexin-33

 Sorting nexin-33 ELISA Kit
 Sorting nexin-33 Recombinant
 Sorting nexin-33 Antibody
Also known as Sorting nexin-33 (SH3 and PX domain-containing protein 3).
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocy
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tosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes ().
 snx33 ELISA Kit
 snx33 Recombinant
 snx33 Antibody
 sh3px3 ELISA Kit
 sh3px3 Recombinant
 sh3px3 Antibody
Table BarTOPTable Bar
 

Sorting nexin-4

 Sorting nexin-4 ELISA Kit
 Sorting nexin-4 Recombinant
 Sorting nexin-4 Antibody
May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation ().
 SNX4 ELISA Kit
 SNX4 Recombinant
 SNX4 Antibody
Table BarTOPTable Bar
 

Sorting nexin-41

 Sorting nexin-41 ELISA Kit
 Sorting nexin-41 Recombinant
 Sorting nexin-41 Antibody
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
 SNX41 ELISA Kit
 SNX41 Recombinant
 SNX41 Antibody
 ADR192C ELISA Kit
 ADR192C Recombinant
 ADR192C Antibody
Table BarTOPTable Bar
 

Sorting nexin-5

 Sorting nexin-5 ELISA Kit
 Sorting nexin-5 Recombinant
 Sorting nexin-5 Antibody
SNX5: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. Belongs to the sorting nexin family.

Protein type: Vesicle

Cellular Component: cell-cell adherens junction; early endosome membrane; endosome; extrinsic to internal side of plasma membrane; extrinsic to membrane; re
>>>
tromer complex

Molecular Function: phosphoinositide binding

Biological Process: endocytosis; pinocytosis; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
 Snx5 ELISA Kit
 Snx5 Recombinant
 Snx5 Antibody
Table BarTOPTable Bar
 

Sorting nexin-6

 Sorting nexin-6 ELISA Kit
 Sorting nexin-6 Recombinant
 Sorting nexin-6 Antibody
SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regul
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ation. Belongs to the sorting nexin family.

Protein type: Vesicle

Cellular Component: cytoplasm; early endosome membrane; endosome; extrinsic to membrane; intracellular membrane-bound organelle; retromer complex

Molecular Function: phosphoinositide binding; protein homodimerization activity

Biological Process: endocytosis; intracellular protein transport; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
 Snx6 ELISA Kit
 Snx6 Recombinant
 Snx6 Antibody
Table BarTOPTable Bar
 

Sorting nexin-7

 Sorting nexin-7 ELISA Kit
 Sorting nexin-7 Recombinant
 Sorting nexin-7 Antibody
SNX7: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. 3 isoforms of the human protein are produced by alternative splicing.

Cellular Component: endosome; extrinsic to membrane

Molecular Function: phosphoinositide binding

Biological Process: endocytosis; vesicle organization and biogenesis
 Snx7 ELISA Kit
 Snx7 Recombinant
 Snx7 Antibody
Table BarTOPTable Bar
 

Sorting nexin-8

 Sorting nexin-8 ELISA Kit
 Sorting nexin-8 Recombinant
 Sorting nexin-8 Antibody
SNX8: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Belongs to the sorting nexin family.

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: early endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; retromer complex

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Molecular Function: identical protein binding; phosphoinositide binding; protein binding

Biological Process: endocytosis; intracellular protein transport; vesicle organization and biogenesis
 SNX8 ELISA Kit
 SNX8 Recombinant
 SNX8 Antibody
Table BarTOPTable Bar
 

Sorting nexin-9

 Sorting nexin-9 ELISA Kit
 Sorting nexin-9 Recombinant
 Sorting nexin-9 Antibody
SNX9: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activa
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tion of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.

Protein type: Vesicle

Cellular Component: cell-cell adherens junction; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; endosome; extrinsic to internal side of plasma membrane; extrinsic to membrane; plasma membrane; trans-Golgi network

Molecular Function: phosphatidylinositol binding; phosphoinositide binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding

Biological Process: cytokinesis after mitosis; endocytosis; endosome transport; intracellular protein transport; positive regulation of GTPase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase activity; positive regulation of protein oligomerization; receptor-mediated endocytosis; vesicle organization and biogenesis
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