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SPARC-related modular calcium-binding protein

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Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.

Below are the list of possible SPARC-related modular calcium-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

SPARC-related modular calcium-binding protein 1

 SPARC-related modular calcium-binding protein 1 ELISA Kit
 SPARC-related modular calcium-binding protein 1 Recombinant
 SPARC-related modular calcium-binding protein 1 Antibody
Also known as SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1).
SMOC1: Plays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation. Defects in SMOC1 are the cause of ophthalmoacromelic syndrome (OAS). A rare disorder presenting with anophthalmia or microphthalmia and limb anomalies. Limb malformatio
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ns include fused 4th and 5th metacarpals and short 5th finger in hands, and olygodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.2

Molecular Function: protein binding

Biological Process: eye development; limb development; regulation of osteoblast differentiation

Disease: Microphthalmia With Limb Anomalies
 SMOC1 ELISA Kit
 SMOC1 Recombinant
 SMOC1 Antibody
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SPARC-related modular calcium-binding protein 2

 SPARC-related modular calcium-binding protein 2 ELISA Kit
 SPARC-related modular calcium-binding protein 2 Recombinant
 SPARC-related modular calcium-binding protein 2 Antibody
Also known as SPARC-related modular calcium-binding protein 2 (Secreted modular calcium-binding protein 2) (SMOC-2).
SMOC2: Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1). A dental defect in which both primary and secondary dentitions are affected. T
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he clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Secreted; Secreted, signal peptide

Cellular Component: basement membrane; proteinaceous extracellular matrix

Molecular Function: glycosaminoglycan binding; heparin binding

Biological Process: extracellular matrix organization and biogenesis
 Smoc2 ELISA Kit
 Smoc2 Recombinant
 Smoc2 Antibody
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