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Spatacsin

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May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.

Below are the list of possible Spatacsin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Spatacsin

 Spatacsin ELISA Kit
 Spatacsin Recombinant
 Spatacsin Antibody
Also known as Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein).
SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite v
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ariable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; lysosomal membrane; nucleolus; plasma membrane; synapse

Molecular Function: protein binding

Biological Process: axon cargo transport; synaptic transmission; synaptic vesicle transport

Disease: Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive
 SPG11 ELISA Kit
 SPG11 Recombinant
 SPG11 Antibody
 KIAA1840 ELISA Kit
 KIAA1840 Recombinant
 KIAA1840 Antibody
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