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Spectrin

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Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.

Below are the list of possible Spectrin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Spectrin alpha chain

 Spectrin alpha chain ELISA Kit
 Spectrin alpha chain Recombinant
 Spectrin alpha chain Antibody
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of f
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urrows during cellularization.
 alpha-Spec ELISA Kit
 alpha-Spec Recombinant
 alpha-Spec Antibody
 SPEC-A ELISA Kit
 SPEC-A Recombinant
 SPEC-A Antibody
 CG1977 ELISA Kit
 CG1977 Recombinant
 CG1977 Antibody
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Spectrin alpha chain, erythrocytic 1

 Spectrin alpha chain, erythrocytic 1 ELISA Kit
 Spectrin alpha chain, erythrocytic 1 Recombinant
 Spectrin alpha chain, erythrocytic 1 Antibody
Also known as Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin).
SPTA1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked for
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m of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3); also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: actin cytoskeleton; cytosol

Molecular Function: actin filament binding; protein binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton

Biological Process: actin filament organization; axon guidance; ER to Golgi vesicle-mediated transport; MAPKKK cascade

Disease: Elliptocytosis 2; Pyropoikilocytosis, Hereditary; Spherocytosis, Type 3
 SPTA1 ELISA Kit
 SPTA1 Recombinant
 SPTA1 Antibody
 SPTA ELISA Kit
 SPTA Recombinant
 SPTA Antibody
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Spectrin alpha chain, non-erythrocytic 1

 Spectrin alpha chain, non-erythrocytic 1 ELISA Kit
 Spectrin alpha chain, non-erythrocytic 1 Recombinant
 Spectrin alpha chain, non-erythrocytic 1 Antibody
Also known as Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain).
Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in mem
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brane organization.
 SPTAN1 ELISA Kit
 SPTAN1 Recombinant
 SPTAN1 Antibody
 SPTA2 ELISA Kit
 SPTA2 Recombinant
 SPTA2 Antibody
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Spectrin beta chain

 Spectrin beta chain ELISA Kit
 Spectrin beta chain Recombinant
 Spectrin beta chain Antibody
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.
 beta-Spec ELISA Kit
 beta-Spec Recombinant
 beta-Spec Antibody
 Spec-b ELISA Kit
 Spec-b Recombinant
 Spec-b Antibody
 CG5870 ELISA Kit
 CG5870 Recombinant
 CG5870 Antibody
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Spectrin beta chain, erythrocytic

 Spectrin beta chain, erythrocytic ELISA Kit
 Spectrin beta chain, erythrocytic Recombinant
 Spectrin beta chain, erythrocytic Antibody
Also known as Spectrin beta chain, erythrocytic (Beta-I spectrin).
SPTB1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTB are the cause of elliptocytosis type 3 (EL3). EL3 is a Rhesus-unlinked form of heredita
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ry elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTB are the cause of spherocytosis type 2 (SPH2); also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q23-q24.2

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; protein complex

Molecular Function: actin binding; actin filament binding; ankyrin binding; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: axon guidance; ER to Golgi vesicle-mediated transport; MAPKKK cascade

Disease: Spherocytosis, Type 2
 SPTB ELISA Kit
 SPTB Recombinant
 SPTB Antibody
 SPTB1 ELISA Kit
 SPTB1 Recombinant
 SPTB1 Antibody
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Spectrin beta chain, non-erythrocytic 1

 Spectrin beta chain, non-erythrocytic 1 ELISA Kit
 Spectrin beta chain, non-erythrocytic 1 Recombinant
 Spectrin beta chain, non-erythrocytic 1 Antibody
Also known as Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain).
SPTBN1: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: axolemma; cell-cell adherens junction; cortical cytoskeleton; cytoplasm; M ban
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d; membrane; nucleolus; nucleus; plasma membrane; postsynaptic density; protein complex

Molecular Function: ankyrin binding; GTPase binding; protein binding; protein complex binding; structural constituent of cytoskeleton

Biological Process: common-partner SMAD protein phosphorylation; cytokinesis after mitosis; Golgi to plasma membrane protein transport; plasma membrane organization and biogenesis; SMAD protein nuclear translocation
 Sptbn1 ELISA Kit
 Sptbn1 Recombinant
 Sptbn1 Antibody
 Elf ELISA Kit
 Elf Recombinant
 Elf Antibody
 Spnb-2 ELISA Kit
 Spnb-2 Recombinant
 Spnb-2 Antibody
 Spnb2 ELISA Kit
 Spnb2 Recombinant
 Spnb2 Antibody
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Spectrin beta chain, non-erythrocytic 2

 Spectrin beta chain, non-erythrocytic 2 ELISA Kit
 Spectrin beta chain, non-erythrocytic 2 Recombinant
 Spectrin beta chain, non-erythrocytic 2 Antibody
Also known as Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41).
SPTBN2: Probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). Spinocerebellar ataxia is a clinically and genetically heteroge
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neous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: apical plasma membrane; cell junction; cell soma; cytoplasm; cytosol; endosome; extracellular space; Golgi membrane; nuclear matrix; perinuclear region of cytoplasm; plasma membrane; spectrin; synaptic vesicle

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: adult behavior; cerebellar Purkinje cell layer morphogenesis; multicellular organism growth; regulation of calcium ion-dependent exocytosis; synaptic vesicle docking during exocytosis; synaptic vesicle exocytosis; synaptogenesis; vesicle-mediated transport
 Sptbn2 ELISA Kit
 Sptbn2 Recombinant
 Sptbn2 Antibody
 Spnb3 ELISA Kit
 Spnb3 Recombinant
 Spnb3 Antibody
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Spectrin beta chain, non-erythrocytic 4

 Spectrin beta chain, non-erythrocytic 4 ELISA Kit
 Spectrin beta chain, non-erythrocytic 4 Recombinant
 Spectrin beta chain, non-erythrocytic 4 Antibody
Also known as Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3).
SPTBN4: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A
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highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: adherens junction; axon hillock; cell soma; cytoplasm; cytosol; membrane; nuclear matrix; plasma membrane; PML body; spectrin

Molecular Function: actin binding; ankyrin binding; phosphatase binding; protein binding; Ras guanyl-nucleotide exchange factor activity; spectrin binding; structural constituent of cytoskeleton

Biological Process: adult walking behavior; axon guidance; axonogenesis; central nervous system projection neuron axonogenesis; clustering of voltage-gated sodium channels; cytoskeletal anchoring; ER to Golgi vesicle-mediated transport; MAPKKK cascade; negative regulation of heart rate; regulation of peptidyl-serine phosphorylation; regulation of sodium ion transport; sensory perception of sound; transmission of nerve impulse; vesicle-mediated transport
 SPTBN4 ELISA Kit
 SPTBN4 Recombinant
 SPTBN4 Antibody
 KIAA1642 ELISA Kit
 KIAA1642 Recombinant
 KIAA1642 Antibody
 SPTBN3 ELISA Kit
 SPTBN3 Recombinant
 SPTBN3 Antibody
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Spectrin beta chain, non-erythrocytic 5

 Spectrin beta chain, non-erythrocytic 5 ELISA Kit
 Spectrin beta chain, non-erythrocytic 5 Recombinant
 Spectrin beta chain, non-erythrocytic 5 Antibody
Also known as Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin).
SPTBN5: Belongs to the spectrin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: cytoplasm; cytosol; photoreceptor connecting cilium

Molecular Function: dynein intermediate chain binding; kinesin binding; myosin tail binding; protein self-association; Ras guanyl-nucleotide exchange factor activity; spectrin binding

Biological Process: axon guidance; ER to Golgi vesicle-mediated transport; Golgi organizat
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ion and biogenesis; lysosomal transport; MAPKKK cascade; protein homooligomerization
 SPTBN5 ELISA Kit
 SPTBN5 Recombinant
 SPTBN5 Antibody
 BSPECV ELISA Kit
 BSPECV Recombinant
 BSPECV Antibody
 HUBSPECV ELISA Kit
 HUBSPECV Recombinant
 HUBSPECV Antibody
 HUSPECV ELISA Kit
 HUSPECV Recombinant
 HUSPECV Antibody
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Proteins Root Name Listing
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