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Sphingosine 1-phosphate receptor

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G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Below are the list of possible Sphingosine 1-phosphate receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sphingosine 1-phosphate receptor 1

 Sphingosine 1-phosphate receptor 1 ELISA Kit
 Sphingosine 1-phosphate receptor 1 Recombinant
 Sphingosine 1-phosphate receptor 1 Antibody
Also known as Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Lysophospholipid receptor B1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363).
EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid
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origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: external side of plasma membrane; intrinsic to plasma membrane

Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding; sphingolipid binding

Biological Process: actin cytoskeleton reorganization; angiogenesis; blood vessel maturation; brain development; cell migration; chemotaxis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; lamellipodium biogenesis; leukocyte chemotaxis; negative regulation of stress fiber formation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of GTPase activity; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of bone mineralization; regulation of bone resorption; regulation of cell adhesion
 S1pr1 ELISA Kit
 S1pr1 Recombinant
 S1pr1 Antibody
 Edg1 ELISA Kit
 Edg1 Recombinant
 Edg1 Antibody
 Lpb1 ELISA Kit
 Lpb1 Recombinant
 Lpb1 Antibody
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Sphingosine 1-phosphate receptor 2

 Sphingosine 1-phosphate receptor 2 ELISA Kit
 Sphingosine 1-phosphate receptor 2 Recombinant
 Sphingosine 1-phosphate receptor 2 Antibody
Also known as Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (AGR16) (Endothelial differentiation G-protein coupled receptor 5) (G-protein coupled receptor H218) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5).
EDG5: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most ty
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pes of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Cellular Component: plasma membrane

Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding; integrin binding

Biological Process: actin cytoskeleton reorganization; filopodium formation
 S1pr2 ELISA Kit
 S1pr2 Recombinant
 S1pr2 Antibody
 Edg5 ELISA Kit
 Edg5 Recombinant
 Edg5 Antibody
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Sphingosine 1-phosphate receptor 3

 Sphingosine 1-phosphate receptor 3 ELISA Kit
 Sphingosine 1-phosphate receptor 3 Recombinant
 Sphingosine 1-phosphate receptor 3 Antibody
Also known as Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Lysophospholipid receptor B3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3).
S1PR3: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family.
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br>Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; integrin binding

Biological Process: cytokine production; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response; Notch signaling pathway; regulation of interleukin-1 beta production
 S1pr3 ELISA Kit
 S1pr3 Recombinant
 S1pr3 Antibody
 Edg3 ELISA Kit
 Edg3 Recombinant
 Edg3 Antibody
 Lpb3 ELISA Kit
 Lpb3 Recombinant
 Lpb3 Antibody
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Sphingosine 1-phosphate receptor 4

 Sphingosine 1-phosphate receptor 4 ELISA Kit
 Sphingosine 1-phosphate receptor 4 Recombinant
 Sphingosine 1-phosphate receptor 4 Antibody
Also known as Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Lysophospholipid receptor C1) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6).
S1PR4: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein
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, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein signaling, adenylate cyclase activating pathway
 S1pr4 ELISA Kit
 S1pr4 Recombinant
 S1pr4 Antibody
 Edg6 ELISA Kit
 Edg6 Recombinant
 Edg6 Antibody
 Lpc1 ELISA Kit
 Lpc1 Recombinant
 Lpc1 Antibody
 S1p4 ELISA Kit
 S1p4 Recombinant
 S1p4 Antibody
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Sphingosine 1-phosphate receptor 5

 Sphingosine 1-phosphate receptor 5 ELISA Kit
 Sphingosine 1-phosphate receptor 5 Recombinant
 Sphingosine 1-phosphate receptor 5 Antibody
Also known as Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Lysophospholipid receptor B4) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8).
EDG8: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect pr
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oliferative activity of these cells. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
 S1pr5 ELISA Kit
 S1pr5 Recombinant
 S1pr5 Antibody
 Edg8 ELISA Kit
 Edg8 Recombinant
 Edg8 Antibody
 Lpb4 ELISA Kit
 Lpb4 Recombinant
 Lpb4 Antibody
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