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Spliceosome RNA helicase

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Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability (By similarity).

Below are the list of possible Spliceosome RNA helicase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Spliceosome RNA helicase Ddx39b

 Spliceosome RNA helicase Ddx39b ELISA Kit
 Spliceosome RNA helicase Ddx39b Recombinant
 Spliceosome RNA helicase Ddx39b Antibody
Also known as Spliceosome RNA helicase Ddx39b (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56).
BAT1: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction
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between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the DEAD box helicase family. DECD subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome

Cellular Component: cytoplasm; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex; spliceosome

Molecular Function: ATP-dependent protein binding; ATP-dependent RNA helicase activity; ATPase activity; protein complex binding; RNA-dependent ATPase activity; U4 snRNA binding; U6 snRNA binding

Biological Process: intronless viral mRNA export from host nucleus; liver development; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; positive regulation of RNA elongation; positive regulation of translation; response to DNA damage stimulus; RNA secondary structure unwinding; RNA splicing; spliceosome assembly
 Ddx39b ELISA Kit
 Ddx39b Recombinant
 Ddx39b Antibody
 Bat1 ELISA Kit
 Bat1 Recombinant
 Bat1 Antibody
 Bat1a ELISA Kit
 Bat1a Recombinant
 Bat1a Antibody
 Uap56 ELISA Kit
 Uap56 Recombinant
 Uap56 Antibody
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Spliceosome RNA helicase DDX39B homolog

 Spliceosome RNA helicase DDX39B homolog ELISA Kit
 Spliceosome RNA helicase DDX39B homolog Recombinant
 Spliceosome RNA helicase DDX39B homolog Antibody
Also known as Spliceosome RNA helicase DDX39B homolog (DEAD box protein UAP56).
Required for mRNA export out of the nucleus. May play a role in spliceosome assembly.
 hel-1 ELISA Kit
 hel-1 Recombinant
 hel-1 Antibody
 C26D10.2 ELISA Kit
 C26D10.2 Recombinant
 C26D10.2 Antibody
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