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Src substrate cortactin

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Contributes to the organization of the actin cytoskeleton and cell shape .

Below are the list of possible Src substrate cortactin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Src substrate cortactin

 Src substrate cortactin ELISA Kit
 Src substrate cortactin Recombinant
 Src substrate cortactin Antibody
Cortactin: a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches. The central region of the protein contains six repeats of 37 amino acids that are important in F-actin binding and cro
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ss-linking. The carboxy-terminus contains a proline-rich region and an SH3 domain that can interact with numerous scaffolding proteins, such as CortBP1 and Shank3. Cortactin may play a role in the organization of transmembrane receptors at postsynaptic densities (PSD) and tight junctions by linking scaffolding proteins to the actin network. It is degraded in a caspase-dependent manner during apoptosis. It is overexpressed in numerous cancers with poor patient prognosis. It may contribute to tumor cell invasion and metastasis. Two splice variant isoforms have been identified.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: actin filament; cell cortex; cell junction; cell-cell adherens junction; coated pit; cortical cytoskeleton; cytoplasm; focal adhesion; Golgi apparatus; growth cone; intracellular membrane-bound organelle; lamellipodium; plasma membrane; podosome; ruffle; voltage-gated potassium channel complex

Molecular Function: profilin binding; protein binding

Biological Process: actin cytoskeleton reorganization; cell motility involved in cell locomotion; focal adhesion formation; intracellular protein transport; neurite morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of axon extension; substrate-bound cell migration, cell extension
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