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Sterile alpha and TIR motif-containing protein

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Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

Below are the list of possible Sterile alpha and TIR motif-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sterile alpha and TIR motif-containing protein 1

 Sterile alpha and TIR motif-containing protein 1 ELISA Kit
 Sterile alpha and TIR motif-containing protein 1 Recombinant
 Sterile alpha and TIR motif-containing protein 1 Antibody
Also known as Sterile alpha and TIR motif-containing protein 1 (Sterile alpha and Armadillo repeat protein) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog).
SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kap
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pa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: cytoplasm; cytosol; dendrite; microtubule; mitochondrion; synapse

Molecular Function: protein binding

Biological Process: negative regulation of MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis
 SARM1 ELISA Kit
 SARM1 Recombinant
 SARM1 Antibody
 KIAA0524 ELISA Kit
 KIAA0524 Recombinant
 KIAA0524 Antibody
 SAMD2 ELISA Kit
 SAMD2 Recombinant
 SAMD2 Antibody
 SARM ELISA Kit
 SARM Recombinant
 SARM Antibody
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Sterile alpha and TIR motif-containing protein tir-1

 Sterile alpha and TIR motif-containing protein tir-1 ELISA Kit
 Sterile alpha and TIR motif-containing protein tir-1 Recombinant
 Sterile alpha and TIR motif-containing protein tir-1 Antibody
Also known as Sterile alpha and TIR motif-containing protein tir-1 (Neuronal symmetry protein 2) (SARM1 homolog).
Required for both innate immune response and specification of AWC(OFF) neuron (PubMed:15048112, PubMed:15123841, PubMed:15625192). During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant r
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eceptor expression (PubMed:15625192). Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31 (PubMed:15048112, PubMed:15123841). Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway (PubMed:15048112, PubMed:15123841, PubMed:15625192). Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1 (PubMed:21212236). In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008).
 tir-1 ELISA Kit
 tir-1 Recombinant
 tir-1 Antibody
 nsy-2 ELISA Kit
 nsy-2 Recombinant
 nsy-2 Antibody
 F13B10.1 ELISA Kit
 F13B10.1 Recombinant
 F13B10.1 Antibody
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